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. 2022 Jun 22;8(25):eabn7162. doi: 10.1126/sciadv.abn7162

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Fig. 5. — (A) Schematic illustration of the vibrating mesh nebulizer device. (B) IVIS imaging of lungs and other organs including heart, liver, spleen, and kidney collected at 24 hours after nebulization of Cy5.5-labeled siIL11@PPGC NPs. Organs from the mice that received PBS treatment were imaged as control. Fluorescence could be observed in all five lobes (N = 3). (C) Quantitative analysis of fluorescence signal in left, cranial, middle, caudal, and accessory lobes (N = 3). (D and E) Subcellular localization of siIL11@PPGC NPs analyzed by flow cytometry (D) and its quantitative assessment (E). Different cell subtypes were marked with corresponding antibodies including anti-CD31 (endothelial), anti-EpCAM (epithelial), and anti-CD45 (immune) (N = 3). Significant differences were assessed using a two-tailed unpaired Student’s t test. Results are presented as means ± SD. **P < 0.01, n.s., not significant, P > 0.05.