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. 2022 Jun 22;8(25):eabn7162. doi: 10.1126/sciadv.abn7162

Fig. 8. Inhalation of siIL11@PPGC NPs restores the pulmonary function in the mouse model of bleomycin-induced pulmonary fibrosis.

Fig. 8.

(A to G) Measurements of pulmonary function parameters including resistance (Rrs) (A), elastance (Ers) (B), inspiratory capacity (IC) (C), compliance (Crs) (D), forced vital capacity (FVC) (E) and forced expiratory volume at 0.2 s (FEV0.2) (F), and static compliance (Cst) (G) (N = 5). (H) Measurements of PV loop (N = 5). (I and J) Correlation analysis between hydroxyproline content and static compliance (Cst) (I) as well as elastance (Ers) (J) (N = 27). Significant differences were assessed using a one-way ANOVA with Tukey test (A to G). Correlation coefficient (r) was assessed using a nonparametric Spearman correlation analysis (I and J). Results are presented as means ± SD. *P < 0.05, **P < 0.01.