Table 1. Summary of mouse liver tumor models.

NA, not applicable.

#	Genotype		Tumori genesis rate	Tumor latency (months)	Tumori genesis pattern*	Histopathological subtype	HCC grade	M_ Cluster	Compare to human HCC					Features
									Transcriptome Hoshida_S	Transcriptome Boyault_G	Proteome Gao_2019	Proteome Jiang_2019	% of TCGA cohort with similar transcriptome by TROM
18	RAS	I	73.7% (I:II = 9:1)	5	3	Steatohepatitic HCC	II	M3	S3	G2	S-Mb	S-I	1.0%	Small tumor, liver metabolic function, lipid storage, glycogen storage
1		II			1 or 2	Mixed cHCC-ICC	NA	M1	S1	G1/G3	S-Me	S-III	20.9%	Large tumor, hepatocyte dedifferentiation, profound fibrosis, immune cell infiltration, proliferation, focal AFP, silence of Hippo, SNUR high risk
2	AKT+NICD		100.0%	2	Mainly 3	ICC	NA	M1	S1/S3	G1	NA	NA	14.4%	Hepatocyte transdifferentiation, profound fibrosis, immune cell infiltration, silence of Hippo, SNUR high risk
3	sgTp53+sgPten		57.1%	8	Mainly 1	Combined cHCC-ICC	NA	M1	S1	G1_2/G6	NA	NA	14.4%	Hepatocyte dedifferentiation, profound fibrosis, Treg infiltration, lipid storage, silence of Hippo, SNUR high risk
4	CTNNB1+NFE2L2		23.1%	12	1	Conventional HCC	II	M1	S1/S3	G3/G6	NA	NA	15.0%	Immune cell infiltration
5	MYC+F/C		57.7%	1	1	Hepatoblastoma	NA	M2	S1/S2	G2/G3	S-Pf	Partial S-III	27.8%	Extramedullary hematopoiesis, proliferation, global AFP, EpCAM signature
6	MYC+AKT		73.1%	1	Mainly 3	Conventional HCC	II	M2	S3	G3	S-Pf	Partial S-III	15.0%	AFP, EpCAM signature
7	CTNNB1+MYC		100.0%	2	2 or 3	Conventional HCC	II-III	M2	S2	G3/G5_6	NA	NA	12.6%	Proliferation, focal AFP, EpCAM signature
8	Tp53 KO+MYC		64.3%	2	1 or 2	Conventional HCC	III	M2	S2/S3	G5/G3	NA	NA	22.2%	Proliferation, global AFP, EpCAM signature, CNV
9	CTNNB1+RAS		91.7%	2	2 or 3	Conventional HCC	II	M2	S2	G3	S-Pf	Partial S-III	19.7%	Bile-filled pseudoglands, AFP, EpCAM signature, moderate fibrosis, silence of Hippo
10	MYC+PI3K		71.4%	2	Mainly 1	Conventional, clear cell, or steatohepatic HCC	II-III	M2	S3	G3/G5	NA	NA	8.6%	Lipid storage, proliferation, global AFP
11	CTNNB1+AKT		40.0%	5	Mainly 2	Conventional HCC	II-III	M2	S2/S3	G3	NA	NA	24.3%	Moderate fibrosis, AFP, EpCAM signature
12	CTNNB1+EGFR		23.7%	3	Mainly 2	Conventional HCC	II	M3	S3	G5/G6	NA	NA	5.7%	Global AFP
13	F/C		50.0%	9	Mainly 1	Conventional HCC	I-II	M3	S3	G5/G6	S-Mb	S-I	8.4%	Lipid storage, cholestasis, SNV, Ctnnb1 mutation
14	MYC		21.4%	9	1 or 2	Conventional HCC	II	M3	S3	G5	NA	NA	2.4%
15	MYC+RAS		72.0%	2	Mainly 3	Steatohepatitic HCC	II	M3	S3	G5	S-Mb	S-I	0.9%	AFP
16	PI3K		43.8%	6	Mainly 2	Conventional, foamy histiocyte-like, or steatohepatic HCC	II-III	M3	S3	G6	NA	NA	12.4%	Lipid storage
17	PI3K+F/C		72.7%	5	Mainly 2	Foamy histiocyte-like HCC	II	M3	S3	G5	NA	NA	8.4%	Lipid storage, cholestasis, SNV, Ctnnb1 mutation

*Tumorigenesis pattern: 1, one to three large tumors per section; 3, many small nodules; 2, intermediate in number and size.