Table 1.
Ten cancer-relevant Reactome pathways from version 66 (V66) selected for evaluation of the predictive accuracy of Reactome pathways
| Reactome pathway identifier | Reactome pathway name | Selected root inputs | Selected key outputs | Test cases | Test cases with available published evidence | Total number of nodes | Total number of edges |
|---|---|---|---|---|---|---|---|
| 68 875 | Mitotic Prophase | 12 | 11 | 264 | 26 | 262 | 273 |
| 69 242 | S Phase | 11 | 9 | 198 | 25 | 409 | 437 |
| 69 620 | Cell Cycle Checkpoints | 7 | 14 | 196 | 55 | 511 | 552 |
| 195 721 | Signaling by WNT | 7 | 37 | 518 | 49 | 817 | 953 |
| 453 279 | Mitotic G1 phase and G1/S transition | 17 | 26 | 884 | 89 | 431 | 556 |
| 1 227 986 | Signaling by ERBB2 | 10 | 9 | 180 | 49 | 212 | 246 |
| 1 257 604 | PIP3 activates AKT signaling | 16 | 14 | 448 | 200 | 781 | 1066 |
| 3 700 989 | Transcriptional Regulation by TP53 | 18 | 51 | 1836 | 257 | 1106 | 1276 |
| 5 673 001 | RAF MAP kinase cascade | 7 | 6 | 84 | 49 | 641 | 834 |
| 5 693 567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 18 | 10 | 360 | 48 | 279 | 310 |