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. 2020 Nov 30;4:100019. doi: 10.1016/j.cpnec.2020.100019

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Effect of ovx on gene expression as (A) ERα in the cortex, (B) ERβ in the cortex, (C) Nrf2 in the cortex (D) HO-1 in the cortex, (E) TNFα in the cortex (F) IL-6 in the cortex (A1) ERα in the hippocampus, (B1) ERβ in the hippocampus, (C1) Nrf2 in the hippocampus (D1) HO-1 in the hippocampus, (E) TNFα in the hippocampus and, (F) IL-6 in the hippocampus. n = 7 in each group. Statistical analysis was performed using Mann-Whitney U test for non-parametric data (ERβ in the cortex) and unpaired student t-test for parametric data (all the remaining parameters). ∗P < 0.05 as compared to sham. sham: Group subjected to surgery; ovx: Group subjected to ovariectomy; ERα: Estrogen receptor alpha; ERβ: Estrogen receptor beta; Nrf2: Nuclear factor erythroid 2 (NFE2)-related factor 2; HO-1: Heme oxygenase-1; TNFα: Tumor necrosis factor alpha and IL-6: Interleukin 6.