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. 2020 Sep 24;23(2):507–521. doi: 10.1093/biostatistics/kxaa037

Table 1.

Simulated performance of logistic regression using different covariates for IR immune response; Inline graphic, or Inline graphic. Sample statistics for different parameters estimates are presented. Inline graphic is the average number of symptomatic vaccinees who arrive and Inline graphic the average number of vaccinees who arrive with the case disease. 1000 test negative designs are simulated for each row. The last row has Inline graphic all other rows have Inline graphic Each row is based on 10 000 simulated studies.

Inline graphic Inline graphic IR Inline graphic Inline graphic % Reject Inline graphic Inline graphic
0.000 1.000 Inline graphic Inline graphic 0.002 0.019 0.053 1049 302
Inline graphic 0.600 1.000 Inline graphic Inline graphic 0.602 0.024 0.973 972 225
Inline graphic 1.810 1.000 Inline graphic Inline graphic 1.821 0.040 1.000 908 160
0.000 0.700 Inline graphic Inline graphic 0.001 0.040 0.048 1048 302
Inline graphic 0.600 0.700 Inline graphic Inline graphic 0.605 0.049 0.786 973 225
Inline graphic 1.810 0.700 Inline graphic Inline graphic 1.826 0.076 1.000 909 160
0.000 0.400 Inline graphic 0.003 0.122 0.049 1049 302
Inline graphic 0.600 0.400 Inline graphic Inline graphic 0.603 0.152 0.332 973 225
Inline graphic 1.810 0.400 Inline graphic Inline graphic 1.827 0.232 0.974 909 160
0.000 0.700 Inline graphic Inline graphic 0.001 0.020 0.048 1048 302
Inline graphic 0.600 0.700 Inline graphic Inline graphic 0.423 0.024 0.790 973 225
Inline graphic 1.810 0.700 Inline graphic Inline graphic 1.274 0.035 1.000 909 160
0.000 0.400 Inline graphic 0.001 0.019 0.048 1049 302
Inline graphic 0.600 0.400 Inline graphic Inline graphic 0.239 0.023 0.344 973 225
Inline graphic 1.810 0.400 Inline graphic Inline graphic 0.725 0.032 0.984 909 160
Inline graphic 0.600 1.000 Inline graphic Inline graphic 0.604 0.031 0.938 599 225