Figure 2.
In vitro screens identify common sensitivity and resistance hits.
(A) STRING148 clustering of significant hits determining tumor sensitivity to immune pressure in vitro, from at least four screens. Significance was determined by the original authors as P < 0.05 or FDR < 0.05. Murine gene symbols were translated to their human paralogs by SynGO.149 (B) Gene ontology enrichment scores of the eight top Reactome gene sets by Panther,150 based on in vitro sensitivity hits identified in at least three screens. Gene sets larger than 500 genes were excluded. (C) STRING148 clustering of significant hits determining tumor resistance to immune pressure in vitro, from at least four screens. Significance was determined by the original authors as P < 0.05 or FDR < 0.05. Murine gene symbols were translated to their human paralogs by SynGO.149 (D) Gene ontology enrichment scores of the eight top Reactome gene sets by Panther,150 based on in vitro sensitivity hits identified in at least three screens. Gene sets larger than 500 genes were excluded.
CASP8, caspase 8; ER, endoplasmic reticulum; FDR, false discovery rate; MHC, major histocompatibility complex; NFκB, nuclear factor-kappa B; NLR, NOD-like receptor; TNF, tumor necrosis factor; TNFR1, tumor necrosis factor receptor 1.