. 2021 Oct 28;11:100043. doi: 10.1016/j.iotech.2021.100043

Table 1.

Common T-cell resistance mechanisms

Type of resistance	Example
Lack of T-cell infiltration	Genetically driven, active T-cell exclusion¹⁹^,²³
Lack of actionable antigens	Low expression of antigenic transcripts²⁶^,²⁷^,²⁹
Defects in antigen presentation	Loss of B2M heterozygosity³⁰ B2M mutations²⁹^,³²^,⁶⁶
Insensitivity to T cell effector molecules	IFN-γ pathway mutations³²^,³⁶^,³⁹ Caspase 8 mutations²²

IFN-γ, interferon-γ.