Table 2.
Differentially secreted angiogenic proteins in SARS-CoV-2-infected HBMECs.
| Analyte name (alternate nomenclature) |
Gene ID |
Foreground pixel intensity (fold change relative to Mock) |
||
|---|---|---|---|---|
| Mock | MOI 0.01 | MOI 0.1 | ||
| Activin-A | 3624 | 55.5 | 32.5 (0.6) | 88.5 (1.63) |
| ADAMTS-1 | 9510 | 25.5 | 12.5 (0.52) | 45.5 (1.88) |
| Angiogenin (ANG) | 283 | 6427 | 7818 (1.21) | 6553 (1.01) |
| Angiopoietin-1 (Ang-1) | 284 | 147 | 86 (0.59) | 155 (1.07) |
| Angiopoietin-2 (Ang-2) | 285 | 39.5 | 12 (0.32) | 79.5 (2.08) |
| Angiostatin/ Plasminigen | 5340 | 144.5 | 10 (0.07) | 74 (0.52) |
| Amphiregulin (AR) | 374 | 5797 | 6744 (1.16) | 5064.5 (0.87) |
| Artemin | 9048 | 144.5 | 143 (0.99) | 64 (0.46) |
| Coagulation Factor III (TF) | 2152 | 818 | 887 (1.08) | 622 (0.76) |
| CXCL16 | 58191 | 3387.5 | 3976.5 (1.17) | 2521.5 (0.74) |
| DPPIV (CD26) | 1803 | 72.5 | 1.5 (0.03) | 203 (2.83) |
| EGF | 1950 | 16.5 | 18 (1.15) | 40.5 (2.60) |
| EG-VEGF (PK1) | 84432 | 188.5 | 164 (0.88) | 257 (1.38) |
| Endoglin (CD105) | 2022 | 17.5 | 17.5 (1.05) | 74.5 (4.40) |
| Endostatin/ Collagen XVIII | 80781 | 3827 | 4747.5 (1.24) | 3931.5 (1.02) |
| Endothelin-1 (ET-1) | 1906 | 9087.5 | 9213 (1.01) | 9007.5 (0.99) |
| FGF acidic (FGF-1) | 2246 | 475 | 69.5 (0.15) | 472.5 (1) |
| FGF basic (FGF2) | 2247 | 16.5 | 5 (0.36) | 4.5 (0.42) |
| FGF-4 | 2249 | 0.5 | −1 | 36.5 (78.0) |
| FGF-7 (KGF) | 2252 | 77.5 | 15.5 (0.21) | 180 (2.34) |
| GDNF | 2668 | 101 | 82 (0.82) | 105 (1.06) |
| GM-CSF | 1437 | 419.5 | 275 (0.65) | 241.5 (0.58) |
| HB-EGF | 1839 | 71 | 32.5 (0.47) | 134 (1.92) |
| HGF | 3082 | 10.5 | 11 (1.14) | 25.5 (2.66) |
| IGFBP-1 | 3484 | 4841.5 | 4901 (1.01) | 4684.5 (0.96) |
| IGFBP-2 | 3485 | 118 | 22.5 (0.19) | 154.5 (1.33) |
| IGFBP-3 | 3486 | 3203 | 5335.5 (1.66) | 3991 (1.24) |
| IL-1β (IL-1F2) | 3553 | 512 | 470.5 (0.92) | 695.5 (1.36). |
| IL-8 (CXCL8) | 3576 | 10875.5 | 10484.5 (0.96) | 10744 (0.98) |
| LAP (TGF B1) | 7040 | 292.5 | 219.5 (0.75) | 102 (0.35) |
| Leptin | 3952 | 1 | 44 (45.0) | 43.5 (46.0) |
| MCP-1 (CCL2) | 6347 | 4549 | 7624 (1.67) | 4759 (1.04) |
| MIP-1A (CCL3) | 6348 | 123 | 103 (0.84) | 149 (1.23) |
| MMP-8 | 4317 | 418 | 510.5 (1.22) | 841.5 (2.01) |
| MMP-9 | 4318 | 298.5 | 106.5 (0.36) | 206 (0.69) |
| NRG1-B1 (HRG1-β1) | 3084 | 256 | 107.5 (0.42) | 320 (1.25) |
| Pentraxin-3 (TSG-14) | 5806 | 7509.5 | 7263.5 (0.96) | 8523 (1.13) |
| PD-ECGF | 1890 | 441 | 310 (0.70) | 600 (1.36) |
| PDGF-AA | 5154 | 1411.5 | 2129.5 (1.50) | 1736.5 (1.23) |
| PDGF-AB/ PDGF-BB | 5155 | 923.5 | 878 (0.95) | 1161 (1.25) |
| Persephin | 5623 | 565.5 | 375.5 (0.66) | 490.5 (0.87) |
| Platelet Factor 4 (CXCL4) | 5196 | 261.5 | 150.5 (0.58) | 283.5 (1.09) |
| PIGF | 5228 | 50.5 | 14 (0.29) | 90 (1.83) |
| Prolactin | 5617 | 7 | 49 (7.14) | 57 (8.5) |
| Serpin B5 (Maspin) | 5268 | 604 | 578 (0.95) | 694 (1.15) |
| Serpin-E1 (PAI-1) | 5054 | 10979.5 | 10955.5 (0.99) | 11590.5 (1.05) |
| Serpin-F1 (PEDF) | 5176 | 422.5 | 327.5 (0.77) | 476 (1.13) |
| TIMP-1 | 7076 | 9548 | 9156 (0.95) | 10696 (1.12) |
| TIMP-4 | 7079 | 446.5 | 292.5 (0.65) | 656.5 (1.47) |
| Thrombospondin-1 (TSP-1) | 7057 | 9842 | 9012 (0.91) | 9727.5 (0.98) |
| Thrombospondin-2 (TSP-2) | 7058 | 688 | 929 (1.35) | 837 (1.22) |
| uPA | 5328 | 12865 | 13396.5 (1.04) | 14065 (1.09) |
| Vasohibin | 22846 | 253 | 172 (0.68) | 268 (1.06) |
| VEGF | 7422 | 9700.5 | 9954 (10.2) | 10559.5 (1.08) |
| VEGF-C | 7424 | 0.5 | 0 | 37 (79.0) |
Analytes in bold had at least 3,000 pixels and were considered as valid signal, as shown in Fig. 4.