Table 1:

Patient Characteristics

	Acutea (N=6)	Rebound after NMV-r (N=6)	Lateb (N=2)
Gender
Male	2 (33%)	3 (50%)	1 (50%)
Female	4 (67%)	3 (50%)	1 (50%)
Age (years)
Median [Min, Max]	49.5 [33, 65]	42.5 [33, 74]	38.5 [23, 54]
Comorbidities
None	1 (17%)	0 (0%)	2 (100%)
Pulmonary	1 (17%)	2 (33%)	0 (0%)
Immunocompromisedc	2 (33%)	2 (33%)	0 (0%)
Cardiac	0 (0%)	2 (33%)	0 (0%)
Other	2 (33%)	0 (0%)	0 (0%)
Days from initial symptom onset to visit
Median [Min, Max]	3 [2, 4]	16 [11, 17]	11 [8, 14]
Initial symptoms
Upper respiratory only	2 (33%)	2 (33%)	0 (0%)
Upper and lower respiratory symptoms	2 (33%)	1 (17%)	1 (50%)
Upper respiratory and constitutional	1 (17%)	3 (50%)	1 (50%)
Upper respiratory, lower respiratory, and constitutional	1 (17%)	0 (0%)	0 (0%)
Received NMV-r
NMV-r Recipients	4 (67%)	6 (100%)	0 (0%)
NMV-r Nonrecipients	2 (33%)	0 (0%)	2 (100%)
Day of illness NMV-r started
Median [Min, Max]	2.50 [2, 3]	2.50 [1, 4]	NA
Day of illness symptoms returned
Median [Min, Max]	13 [11, 15]	12.5 [11, 15]d	9 [rebound patient only]
Day symptoms returned after completing NMV-r
Median [Min, Max]	6 [4, 8]	6.50 [3, 9]	NA

^aTwo patients were seen during both their initial acute episode as well as during rebound symptoms. Their first timepoint was included in the “acute” group, and their second timepoint in the “NMV-r rebound” group. They both had symptom resolution and negative antigen tests after completing NMV-r with symptom return and positive antigen tests at eight and five days after completing NMV-r, respectively. See supplemental table 3 for further details (patient 1 and patient 2).

^bThe NMV-r nonrecipient rebound patient presented 14 days after symptom onset and was included alongside a control who had presented 8 days after symptom onset in the “late” group.

^cImmunocompromising conditions across the entire cohort include multiple sclerosis, idiopathic thrombocytopenic purpura, ankylosing spondylitis, and primary biliary cirrhosis

^dFour rebound patients repeated rapid antigen tests after initial symptom resolution. Three became negative and the fourth became weakly positive. All four became positive again when rebound symptoms returned.