TABLE 3.
HRs (95% CIs) for mortality by level of adherence to the 2018 WCRF/AICR score (0–7 points) in males by smoking status1
| Continuous | 2018 WCRF/AICR score a priori categories | |||||
|---|---|---|---|---|---|---|
| Cases/person-years | Model2 | HR (95% CI) | 0–2 (n = 9385) | >2 to <5 (n = 81,578) | 5–7 (n = 3891) | |
| All-cause | ||||||
| Never smoker | 2449/487,023 | Univariate | 0.88 (0.84–0.92) | 1.00 (Ref) | 0.61 (0.54–0.69) | 0.64 (0.52–0.78) |
| Multivariate | 0.85 (0.81–0.89) | 1.00 (Ref) | 0.58 (0.52–0.66) | 0.57 (0.46–0.70) | ||
| Former smoker | 623/738,947 | Univariate | 0.84 (0.82–0.87) | 1.00 (Ref) | 0.68 (0.63–0.73) | 0.58 (0.49–0.69) |
| Multivariate | 0.81 (0.78–0.83) | 1.00 (Ref) | 0.64 (0.59–0.69) | 0.51 (0.43–0.61) | ||
| Current smoker | 1593/107,224 | Univariate | 0.92 (0.86–0.97) | 1.00 (Ref) | 0.79 (0.69–0.90) | 0.62 (0.38–1.00) |
| Multivariate | 0.82 (0.83–0.93) | 1.00 (Ref) | 0.74 (0.65–0.85) | 0.55 (0.34–0.89) | ||
| All cancers | ||||||
| Never smoker | 677/487,023 | Univariate | 0.93 (0.86–1.01) | 1.00 (Ref) | 0.82 (0.63–1.05) | 0.90 (0.62–1.33) |
| Multivariate | 0.91 (0.84–0.99) | 1.00 (Ref) | 0.78 (0.60–1.000) | 0.84 (0.57–1.24) | ||
| Former smoker | 1767/107,224 | Univariate | 0.90 (0.85–0.95) | 1.00 (Ref) | 0.78 (0.68–0.90) | 0.65 (0.47–0.88) |
| Multivariate | 0.87 (0.82–0.92) | 1.00 (Ref) | 0.74 (0.64–0.85) | 0.59 (0.43–0.81) | ||
| Current smoker | 598/7831 | Univariate | 1.05 (0.95–1.16) | 1.00 (Ref) | 1.07 (0.84–1.36) | 0.84 (0.39–1.81) |
| Multivariate | 1.02 (0.93–1.13) | 1.00 (Ref) | 1.02 (0.80–1.30) | 0.81 (0.37–1.76) | ||
| CVD | ||||||
| Never smoker | 745/487,023 | Univariate | 0.88 (0.81–0.95) | 1.00 (Ref) | 0.55 (0.45–0.67) | 0.59 (0.42–0.84) |
| Multivariate | 0.84 (0.77–0.91) | 1.00 (Ref) | 0.51 (0.41–0.63) | 0.51 (0.35–0.73) | ||
| Former smoker | 1500/738,947 | Univariate | 0.83 (0.79–0.88) | 1.00 (Ref) | 0.70 (0.61–0.82) | 0.56 (0.40–0.79) |
| Multivariate | 0.79 (0.75–0.84) | 1.00 (Ref) | 0.66 (0.57–0.76) | 0.48 (0.34–0.68) | ||
| Current smoker | 380/107,224 | Univariate | 0.86 (0.75–0.97) | 1.00 (Ref) | 0.71 (0.54–0.93) | 0.53 (0.19–1.44) |
| Multivariate | 0.81 (0.71–0.92) | 1.00 (Ref) | 0.67 (0.51–0.87) | 0.44 (0.16–1.21) | ||
1
n = 94,854. Attained person-years as the underlying time metric. The total and mean follow-up time for males was 1,333,194 person-years and 14.1 person-years, respectively. AICR, American Institute for Cancer Research, CVD, cardiovascular disease; Ref, reference; WCRF, World Cancer Research Fund.
2
Multivariate model adjusted for age, race/ethnicity (White, other), marital status (married, other), education (less than high school, high school graduate, some college, college graduate), total energy (continuous), and diabetes (yes/no).