TABLE 4.
HRs (95% CIs) for mortality by level of adherence to the 2018 WCRF/AICR score (0–7 points) in females by smoking status1
| Continuous | 2018 WCRF/AICR score a priori categories | |||||
|---|---|---|---|---|---|---|
| Cases/person-years | Model2 | HR (95% CI) | 0–2 (n = 6738) | >2 to <5 (n = 68,569) | 5–7 (n = 7249) | |
| All-cause | ||||||
| Never smoker | 2378/588,883 | Univariate | 0.82 (0.79–0.86) | 1.00 (Ref) | 0.57 (0.51–0.65) | 0.50 (0.42–0.60) |
| Multivariate | 0.82 (0.79–0.85) | 1.00 (Ref) | 0.59 (0.52–0.67) | 0.50 (0.41–0.60) | ||
| Former smoker | 2519/467,396 | Univariate | 0.78 (0.75–0.81) | 1.00 (Ref) | 0.54 (0.48–0.60) | 0.36 (0.30–0.44) |
| Multivariate | 0.78 (0.75–0.81) | 1.00 (Ref) | 0.56 (0.50–0.63) | 0.38 (0.31–0.46) | ||
| Current smoker | 1493/132,689 | Univariate | 0.81 (0.77–0.86) | 1.00 (Ref) | 0.65 (0.57–0.75) | 0.51 (0.38–0.69) |
| Multivariate | 0.78 (0.74–0.82) | 1.00 (Ref) | 0.62 (0.54–0.71) | 0.44 (0.32–0.59) | ||
| All cancers | ||||||
| Never smoker | 723/588,883 | Univariate | 0.88 (0.82–0.95) | 1.00 (Ref) | 0.70 (0.55–0.90) | 0.61 (0.44–0.86) |
| Multivariate | 0.86 (0.80–0.93) | 1.00 (Ref) | 0.70 (0.54–0.789) | 0.57 (0.40–0.80) | ||
| Former smoker | 801/467,396 | Univariate | 0.85 (0.79–0.91) | 1.00 (Ref) | 0.64 (0.51–0.79) | 0.51 (0.37–0.72) |
| Multivariate | 0.85 (0.79–0.91) | 1.00 (Ref) | 0.65 (0.52–0.81) | 0.52 (0.37–0.73) | ||
| Current smoker | 514/132,689 | Univariate | 0.93 (0.85–1.02) | 1.00 (Ref) | 0.85 (0.66–1.11) | 0.61 (0.36–1.06) |
| Multivariate | 0.91 (0.83–0.998) | 1.00 (Ref) | 0.83 (0.64–1.07) | 0.55 (0.32–0.96) | ||
| CVD | ||||||
| Never smoker | 649/588,883 | Univariate | 0.79 (0.73–0.85) | 1.00 (Ref) | 0.50 (0.42–0.61) | 0.37 (0.27–0.50) |
| Multivariate | 0.79 (0.73–0.86) | 1.00 (Ref) | 0.57 (0.45–0.72) | 0.43 (0.30–0.61) | ||
| Former smoker | 610/467,396 | Univariate | 0.73 (0.67–0.79) | 1.00 (Ref) | 0.53 (0.42–0.66) | 0.26 (0.17–0.40) |
| Multivariate | 0.74 (0.68–0.80) | 1.00 (Ref) | 0.55 (0.44–0.70) | 0.27 (0.17–0.42) | ||
| Current smoker | 316/132,689 | Univariate | 0.80 (0.71–0.90) | 1.00 (Ref) | 0.58 (0.44–0.78) | 0.59 (0.32–1.07) |
| Multivariate | 0.76 (0.67–0.85) | 1.00 (Ref) | 0.54 (0.40–0.73) | 0.47 (0.26–0.86) | ||
1
n = 82,556. Attained person-years as the underlying time metric. The total and mean follow-up time for females was 1,188,968 person-years and 14.4 person-years, respectively. AICR, American Institute for Cancer Research, CVD, cardiovascular disease; Ref, reference; WCRF, World Cancer Research Fund.
2
Multivariate model adjusted for age, race/ethnicity (White, other), marital status (married, other), education (less than high school, high school graduate, some college, college graduate), total energy (continuous), hormone replacement therapy (never, former, current), and diabetes (yes/no).