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Thermodynamic parameters of nsP4-CHIKV unfolding by CD spectroscopy.
| Rate (°C/min) | Tm (°C) | ΔHapp (kcal/mol) | ΔSapp (cal/mol K) |
|---|---|---|---|
| 0.5 | 41.8 ± 0.2 | 122 ± 12 | 387 ± 38 |
| 1.0 | 43.7 ± 0.2 | 104 ± 8 | 331 ± 26 |
The Tm and the ΔHapp were determined by fitting the CD data to a two-state equilibrium model28. The ΔSapp of the unfolding transition at Tm was calculated as ΔSapp = ΔHapp/Tm since ΔG = 0 at Tm.
