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Pathogenesis of glucocorticoid resistance. A Consequences of GR mutations on the hypothalamic–pituitary axis causing hypercortisolism. ACTH adenocorticotropic hormone; CRH corticotropin-releasing hormone B Linear model of the human GR structure and localization of identified mutations. C Linear structure of rodent GRs carrying the mutant em2, em4 and β geo allele; NTD N-terminus domain, DBD DNA binding domain, HR hinge region, LBD ligand binding domain
