Table 2.

Overview of rodent models with altered GR expression and their phenotype

Nomenclature	Rodent model and study conditions	Adrenal hyperplasia	Corticosterone (Basal)	Blood Pressure	Ref
GRNFLAsGR	KO, constitutive Standard diet	Yes	Elevated	Not reported	[54]
GR+/−	Heterozygotes, constitutive Standard diet	Yes	Elevated	Not reported	[16]
GRloxP;Tie−1−Cre+	KO, vascular endothelium	Not reported	Not reported	Dexamethasone-induced hypertension	[66][22]
GRloxP;Ksp−Cre+	KO, distal nephron Dexamethasone (15 mg/L)	Not reported	Not reported	Less elevated following dexamethasone treatment	[21]
GRβgeo/+	Heterozygotes, constitutive Standard diet	Yes	Elevated	Elevated	[40]
Nr3c1Pax8/LC1	KO, kidney tubule- specific KO, High salt diet	Not reported	Not reported	Diastolic BP dipping increased following high salt	[8]
GR+/em2	Heterozygotes, High salt diet	Yes	Elevated	Elevated following high salt	[55][68]

KO knockout, BP blood pressure