TABLE 4.
List of upregulated proteins during estrus (E) vs. proestrus (PE), metestrus (ME), and diestrus (DE) stages using TMT-LC-MS/MS analysis.
| Accession | Gene symbol | Description | Peptide | Fold change E/PE | Fold change E/ME | Fold change E/DE |
|---|---|---|---|---|---|---|
| F1MKI5 | SDF4 | 45-kDa calcium-binding protein | 2 | 71.71 | 100 | 19.73 |
| Q3ZBZ1 | SDF4 | 45-kDa calcium-binding protein | 3 | 62.663 | 88.648 | 19.262 |
| Q2NKS8 | LOC526524 | Peptidyl-prolyl isomerase | 1 | 13.678 | 17.355 | 37.984 |
| E1BKA1 | LOC786350 | Protein S100 | 1 | 14.447 | 19.419 | 1.34 |
| G3MZ21 | — | Uncharacterized protein | 1 | 13.057 | 8.159 | 2.728 |
| E1BEL8 | HBE1 | Globin B1 | 1 | 13.057 | 8.159 | 2.728 |
| E1BEL7 | HSPB1 | Heat shock protein beta-1 | 6 | 12.524 | 15.547 | 7.289 |
| Q58DP7 | HSPB1 | Heat shock 27-kDa protein 1 | 5 | 12.524 | 15.547 | 7.289 |
| G3X7S2 | HSPB1 | Heat shock protein beta-1 | 5 | 12.524 | 15.547 | 7.289 |
| Q5KR47 | TPM3 | Tropomyosin alpha-3 chain | 1 | 11.813 | 13.017 | 1.782 |
| A6QR15 | LOC535277 | LOC535277 protein | 1 | 11.813 | 13.017 | 1.782 |
| Q5KR48 | TPM2 | Tropomyosin beta chain | 1 | 11.813 | 13.017 | 1.782 |
| Q5KR47-2 | TPM3 | Isoform 2 of Tropomyosin alpha-3 chain | 1 | 11.813 | 13.017 | 1.782 |
| P81947 | TUBA1B; TUBA1A | Tubulin alpha-1B chain | 2 | 11.444 | 12.223 | 5.148 |
| F1MNF8 | LOC100141266 | Tubulin alpha chain | 1 | 11.444 | 12.223 | 5.148 |
| G3X700 | LOC104969973 | Uncharacterized protein | 7 | 11.348 | 14.639 | 5.809 |
| Q862B8 | TIMP2 | Similar to metalloproteinase inhibitor | 3 | 11.285 | 11.992 | 2.762 |
| P07435 | OBP | Odorant-binding protein | 8 | 2.573 | 2.481 | 69.029 |
| Q862Q0 | PGAM1 | Phosphoglycerate mutase | 1 | 3.695 | 5.268 | 48.354 |
| Q0IIA2 | MGC151921 | Odorant-binding protein-like | 5 | 1.784 | 2.753 | 23.736 |
| A5PJH7 | LOC788112 | LOC788112 protein | 1 | 2.292 | 1.987 | 21.114 |
| A8KC76 | HSPA8 | HSPA8 protein | 1 | 4.673 | 4.937 | 18.413 |
| Q865V6 | CAPG | Macrophage-capping protein | 1 | 3 | 3.531 | 14.154 |
| Q3ZCL8 | SH3BGRL3 | SH3 domain-binding glutamic acid-rich-like protein 3 | 2 | 2.104 | 2.295 | 12.421 |
| F1MS23 | LCN1 | Lipocalin 1 | 6 | 7.354 | 14.39 | 11.301 |
| P02070 | HBB | Hemoglobin subunit beta | 9 | 9.977 | 6.41 | 2.243 |
| F1MKC4 | — | Uncharacterized protein | 5 | 9.876 | 9.214 | 2.063 |
| Q58DT9 | ACTA2 | Alpha 2 actin | 9 | 9.561 | 8.913 | 2.069 |
| G8JKX4 | ACTA2 | Actin, aortic smooth muscle | 9 | 9.561 | 8.913 | 2.069 |
| E1BLR9 | CPD | Carboxypeptidase D | 1 | 8.519 | 11.821 | 3.381 |
| P60712 | ACTB | Actin, cytoplasmic 1 | 17 | 8.154 | 7.925 | 2.061 |
| F1MRD0 | ACTB | Actin, cytoplasmic 1 | 14 | 8.154 | 7.925 | 2.061 |
| P81265-2 | PIGR | Isoform short of polymeric immunoglobulin receptor | 15 | 7.975 | 8.284 | 5.803 |
| G5E6M1 | PIGR | Polymeric immunoglobulin receptor | 14 | 7.975 | 8.284 | 5.803 |
| G3N2H5 | S100A12 | Protein S100 | 1 | 7.311 | 3.613 | 2.133 |
| A0A1C9EIX6 | HSPB1 | Heat shock protein family B member 1 variant 2 | 7 | 6.972 | 7.193 | 5.125 |
| F1N650 | ANXA1 | Annexin | 2 | 6.562 | 4.819 | 0.855 |
| Q712W6 | GAPDH | Glyceraldehyde 3-phosphate dehydrogenase | 3 | 5.445 | 4.678 | 0.97 |
| E1BDE6 | LGALS7B | Galectin | 6 | 5.339 | 6.629 | 4.633 |
| G3N3D0 | LGALS7 | Galectin | 6 | 5.339 | 6.629 | 4.633 |
| G3MX66 | VMO1 | Vitelline membrane outer layer 1 homolog | 5 | 5.3 | 5.5 | 4.1 |
| P81265 | PIGR | Polymeric immunoglobulin receptor | 29 | 5.127 | 5.514 | 4.049 |
| A6QNW3 | PIGR | PIGR protein | 29 | 5.127 | 5.514 | 4.049 |
| G5E5C8 | TALDO1 | Transaldolase | 3 | 4.986 | 4.795 | 1.281 |
| A5D7E8 | PDIA3 | Protein disulfide-isomerase | 2 | 4.969 | 3.617 | 1.212 |
| E1B970 | GOLGA3 | Golgin A3 | 1 | 4.283 | 5.078 | 6.458 |
| A6QQ07 | BTD | Biotinidase | 1 | 3.945 | 3.735 | 2.313 |
| Q0P569 | NUCB1 | Nucleobindin-1 | 9 | 3.793 | 3.702 | 4.757 |
| P68252 | YWHAG | 14-3-3 protein gamma | 2 | 3.757 | 4.645 | 9.328 |
| G3X894 | LOC786263 | Uncharacterized protein | 5 | 3.71 | 5.005 | 0.897 |
| Q629I2 | RPVgp5 | Fusion glycoprotein F0 | 1 | 3.705 | 4.751 | 3.904 |
| P05307 | P4HB | Protein disulfide-isomerase | 3 | 3.338 | 3.649 | 9.38 |
| Q3SZ62 | PGAM1 | Phosphoglycerate mutase 1 | 6 | 3.21 | 3.424 | 3.828 |
| G3X799 | OBP | Uncharacterized protein | 9 | 3.041 | 2.813 | 2.032 |
| F1N614 | HSPA5 | 78-kDa glucose-regulated protein | 2 | 3.018 | 3.507 | 2.316 |
| Q2KJF1 | A1BG | Alpha-1B-glycoprotein | 2 | 2.625 | 2.919 | 2.931 |
| Q3T145 | MDH1 | Malate dehydrogenase, cytoplasmic | 2 | 2.547 | 2.689 | 1.172 |
| F1N3A1 | THBS1 | Thrombospondin-1 | 10 | 2.524 | 2.7 | 0.95 |
| F1MKE7 | KRT6C | Uncharacterized protein | 9 | 2.385 | 3.018 | 4.091 |
| Q3T010 | PEBP4 | Phosphatidylethanolamine-binding protein 4 | 2 | 2.212 | 3.24 | 2.012 |
| F2FB41 | MUC5AC | Mucin-5AC | 6 | 2.197 | 3.168 | 1.523 |
| Q3SZH5 | AGT | Angiotensinogen | 4 | 1.98 | 1.909 | 2.112 |
| F2Z4I6 | HIST2H2AC | Histone H2A | 5 | 1.928 | 2.208 | 2.153 |
| A1A4R1 | HIST2H2AC | Histone H2A type 2-C | 5 | 1.928 | 2.208 | 2.153 |
| F1MRN2 | — | Histone H2A | 3 | 1.928 | 2.208 | 2.153 |
| F1MLQ1 | LOC524236 | Histone H2A | 2 | 1.928 | 2.208 | 2.153 |
| Q862L0 | ACTG2 | Similar to beta-actin | 4 | 1.745 | 1.596 | 3.548 |
| F1MB90 | OVOS2 | Uncharacterized protein | 16 | 1.726 | 2.819 | 1.215 |
| F6QEL0 | — | Cystatin | 2 | 1.427 | 1.338 | 3.907 |
| Q5DPW9 | CST6 | Cystatin | 2 | 1.427 | 1.338 | 3.907 |
| F1MVR7 | FAM25A | Uncharacterized protein | 1 | 1.378 | 1.946 | 1.935 |
| E1BI89 | LOC101908058 | Uncharacterized protein | 4 | 1.355 | 1.541 | 2.142 |
| K4JDT2 | A2M | Alpha-2-macroglobulin variant 20 | 12 | 1.243 | 2.308 | 8.216 |
| F1N4C3 | BPIFA2B | Uncharacterized protein | 3 | 0.428 | 0.285 | 1.713 |