TABLE 5.
List of downregulated proteins during estrus (E) vs. proestrus (PE), metestrus (ME), and diestrus (DE) stages using TMT-LC-MS/MS analysis.
| Accession | Gene symbol | Description | Peptide | Fold change E/PE | Fold change E/ME | Fold change E/DE |
|---|---|---|---|---|---|---|
| B9TUD2 | CATHL7 | Cathelicidin-7 | 1 | 0.01 | 0.01 | 0.01 |
| G3N1R1 | — | Uncharacterized protein | 1 | 0.01 | 0.01 | 0.063 |
| B9TUC3 | CATHL2 | Cathelicidin-2 | 1 | 0.01 | 0.01 | 0.01 |
| Q148E6 | CYP4B1 | Cytochrome P450 family 4 subfamily B member 1 | 1 | 0.01 | 0.01 | 0.234 |
| Q1RMN8 | IGL@ | Immunoglobulin light chain, lambda gene cluster | 14 | 0.014 | 0.012 | 0.228 |
| Q28133 | BDA20 | Allergen Bos d 2 | 2 | 0.019 | 0.095 | 0.045 |
| A5D7Q2 | LOC524810 | Uncharacterized protein | 9 | 0.021 | 0.023 | 0.112 |
| K4JR84 | A2M | Alpha-2-macroglobulin variant 17 | 2 | 0.021 | 0.038 | 0.393 |
| E1BI82 | LOC525947 | Uncharacterized protein | 1 | 0.022 | 0.028 | 0.275 |
| G3X6K8 | HP | Haptoglobin | 3 | 0.028 | 0.057 | 0.069 |
| Q3ZCL0 | CRISP3 | Cysteine-rich secretory protein 2 | 3 | 0.032 | 0.038 | 0.021 |
| F6R3I5 | CRISP3 | Uncharacterized protein | 4 | 0.032 | 0.038 | 0.021 |
| P02702 | FOLR1; FOLR3 | Folate receptor alpha | 1 | 0.039 | 0.049 | 0.586 |
| E1B8Q6 | LOC524080 | Uncharacterized protein | 1 | 0.044 | 0.045 | 0.01 |
| F1MD73 | — | Uncharacterized protein | 7 | 0.045 | 0.054 | 0.133 |
| P60986 | PIP; LOC107131147 | Prolactin-inducible protein homolog | 10 | 0.047 | 0.062 | 0.056 |
| F1MCV8 | — | Uncharacterized protein | 3 | 0.047 | 0.062 | 0.056 |
| F1N6D1 | LOC100847724 | Uncharacterized protein | 13 | 0.047 | 0.069 | 0.016 |
| G3N269 | FABP5 | Fatty acid-binding protein, epidermal | 3 | 0.053 | 0.071 | 0.136 |
| F1MHQ2 | BPIFA2A | Uncharacterized protein | 21 | 0.056 | 0.047 | 0.048 |
| Q6PVY3 | MIF | Macrophage migration inhibitory factor | 1 | 0.057 | 0.066 | 0.067 |
| Q6H320 | KLK1 | Glandular kallikrein | 6 | 0.058 | 0.071 | 0.148 |
| A0JNP2 | SCGB1D | Secretoglobin family 1D member | 1 | 0.07 | 0.117 | 0.352 |
| G3N2D7 | LOC100297192 | Uncharacterized protein | 4 | 0.073 | 0.067 | 0.128 |
| K4JR71 | A2M | Alpha-2-macroglobulin variant 2 | 4 | 0.076 | 0.132 | 0.206 |
| P17697 | CLU | Clusterin | 5 | 0.08 | 0.08 | 0.444 |
| E1BL84 | — | Uncharacterized protein | 2 | 0.08 | 0.082 | 0.013 |
| F1MSB7 | PLS3 | Plastin-3 | 9 | 0.082 | 0.091 | 0.036 |
| Q862H7 | S100A11 | Protein S100 | 1 | 0.086 | 0.075 | 0.01 |
| O62672 | MUC19 | Submaxillary mucin 1 | 9 | 0.087 | 0.084 | 0.428 |
| F1MWN7 | — | Uncharacterized protein | 9 | 0.087 | 0.084 | 0.431 |
| F1N0W1 | FCHSD1 | Uncharacterized protein | 6 | 0.091 | 0.161 | 0.07 |
| Q5E9B1 | LDHB | l-Lactate dehydrogenase B chain | 2 | 0.101 | 0.083 | 0.032 |
| G1K1L8 | — | Uncharacterized protein | 9 | 0.106 | 0.117 | 0.104 |
| A6QQF6 | SBSN | Suprabasin | 1 | 0.109 | 0.112 | 0.06 |
| A2VE41 | EFEMP1 | EGF-containing fibulin-like extracellular matrix protein 1 | 14 | 0.12 | 0.099 | 0.161 |
| E1BAU5 | LOC512548; SLPI | Uncharacterized protein | 1 | 0.124 | 0.171 | 0.479 |
| A4IFI0 | IGLL1 | IGLL1 protein | 9 | 0.132 | 0.115 | 0.289 |
| F1MCF8 | LOC100297192 | Uncharacterized protein | 11 | 0.132 | 0.115 | 0.289 |
| A5PK49 | IGL@ | IGL@ protein | 6 | 0.132 | 0.115 | 0.289 |
| A6H7J7 | LOC100297192 | Uncharacterized protein | 9 | 0.139 | 0.121 | 0.297 |
| P02253 | HIST1H1C | Histone H1.2 | 18 | 0.143 | 0.107 | 0.05 |
| F2FB39 | MUC19 | Mucin-19 | 14 | 0.154 | 0.136 | 0.067 |
| G3X6I0 | — | Uncharacterized protein | 10 | 0.172 | 0.213 | 0.246 |
| P19858 | LDHA | l-Lactate dehydrogenase A chain | 21 | 0.172 | 0.134 | 0.032 |
| G3MX67 | — | Uncharacterized protein | 2 | 0.176 | 0.157 | 0.213 |
| F1MBA5 | — | Uncharacterized protein | 6 | 0.176 | 0.157 | 0.213 |
| G3N0H7 | — | Uncharacterized protein | 4 | 0.176 | 0.157 | 0.213 |
| A0A1Y0KDJ6 | — | Beta-casein | 9 | 0.177 | 0.181 | 0.495 |
| F1MGF6 | — | Uncharacterized protein | 13 | 0.181 | 0.165 | 0.052 |
| G9G9X6 | LALBA | Alpha-lactalbumin protein variant D | 14 | 0.188 | 0.254 | 0.352 |
| Q3SYR8 | IGJ; JCHAIN | Immunoglobulin J chain | 10 | 0.19 | 0.166 | 0.191 |
| B2BX69 | AZGP1 | Zn-alpha-2-glycoprotein | 3 | 0.197 | 0.19 | 0.156 |
| B2BX70 | AZGP1 | Zn-alpha-2-glycoprotein | 2 | 0.197 | 0.19 | 0.156 |
| A5D7V3 | ESM1 | ESM1 protein | 2 | 0.213 | 0.297 | 0.145 |
| G5E513 | IGHM | Immunoglobulin heavy constant mu | 5 | 0.219 | 0.455 | 0.126 |
| P01035 | CST3 | Cystatin-C | 6 | 0.221 | 0.184 | 0.302 |
| G5E5Q6 | TFF3 | Trefoil factor 3 | 3 | 0.229 | 0.232 | 0.22 |
| Q6LC78 | LTF | Lactoferrin | 8 | 0.23 | 0.432 | 0.369 |
| G5E5T5 | — | Uncharacterized protein | 8 | 0.231 | 0.459 | 0.424 |
| E1B8Q2 | LOC104969118 | Uncharacterized protein | 5 | 0.241 | 0.216 | 0.775 |
| Q8MII0 | LTF | Lactotransferrin | 8 | 0.244 | 0.388 | 0.394 |
| F1MB32 | A2ML1 | Uncharacterized protein | 3 | 0.244 | 0.318 | 0.087 |
| Q6LBN7 | LTF | Lactoferrin | 18 | 0.254 | 0.424 | 0.295 |
| Q3SZ57 | AFP | Alpha-fetoprotein | 1 | 0.258 | 0.427 | 0.063 |
| Q19KS1 | LTF | Lactoferrin | 7 | 0.269 | 0.484 | 0.223 |
| Q683R8 | Cath | Cathelicidin | 3 | 0.316 | 0.364 | 0.079 |
| A6QQA8 | QSOX1 | Sulfhydryl oxidase | 1 | 0.316 | 0.392 | 0.14 |
| P00432 | CAT | Catalase | 1 | 0.33 | 0.385 | 0.023 |
| P33046 | CATHL4; LOC786887 | Cathelicidin-4 | 1 | 0.377 | 0.335 | 0.058 |
| F1MH40 | — | Uncharacterized protein | 1 | 0.417 | 0.43 | 0.413 |
| X5F5B4 | SERPINB4 | Serpin B4-like protein | 2 | 0.456 | 0.557 | 0.566 |
| A6QPZ4 | SERPINB4 | SERPINB4 protein | 2 | 0.456 | 0.557 | 0.566 |