TABLE 6.
Involvement of differentially expressed proteins (DEPs) in KEGG pathways.
| S.No. | KEGG pathway | Number of genes | Associated gene | p-value |
|---|---|---|---|---|
| 1 | Glycolysis/gluconeogenesis | 15 | ALDOA, ALDOB, ALDOC, ENO1, ENO2, ENO3, GAPDHS, GPI, LDHA, LDHB, LDHC, PGAM1, PGK1, PKLR, and TPI1 | 0.00 |
| 2 | PPAR signaling pathway | 6 | APOA1, DBI, FABP3, FABP4, FABP5, and UBC | 0.00 |
| 3 | Complement and coagulation cascades | 9 | A2M, C3, C4BPA, CFB, CLU, F5, FGA, FGB, and FGG | 0.00 |
| 4 | IL-17 signaling pathway | 5 | LCN2, LOC786350, MUC5AC, MUC5B, and S100A8 | 0.03 |
| 5 | Salivary secretion | 12 | CAMP, CATHL2, CATHL3, CATHL4, CATHL5, CATHL6, CST3, LOC785803, LPO, LYZ2, LYZ3, and MUC5B | 0.00 |
| 6 | Pentose phosphate pathway | 7 | ALDOA, ALDOB, ALDOC, GPI, PGD, TALDO1, and TKT | 0.00 |
| 7 | Fructose and mannose metabolism | 4 | ALDOA, ALDOB, ALDOC, and TPI1 | 0.00 |
| 8 | Cysteine and methionine metabolism | 5 | LDHA, LDHB, LDHC, MDH1, and SDS | 0.00 |
| 9 | Pyruvate metabolism | 5 | LDHA, LDHB, LDHC, MDH1, and PKLR | 0.00 |
| 10 | Propanoate metabolism | 3 | LDHA, LDHB, and LDHC | 0.02 |
| 11 | Glucagon signaling pathway | 5 | LDHA, LDHB, LDHC, PGAM1, and PYGL | 0.03 |
| 12 | VEGF signaling pathway | 3 | RAC1, RAC2, and RAC3 | 0.09 |
| 13 | Adherens junction | 5 | CDH1, CTNNB1, RAC1, RAC2, and RAC3 | 0.01 |
| 14 | B-cell receptor signaling pathway | 4 | LOC100300716, RAC1, RAC2, and RAC3 | 0.05 |
| 15 | Fc epsilon RI signaling pathway | 4 | LOC100300716, RAC1, RAC2, and RAC3 | 0.04 |
| 16 | Fc gamma R-mediated phagocytosis | 5 | CFL1, CFL2, LOC100300716, RAC1, and RAC2 | 0.02 |
| 17 | Fluid shear stress and atherosclerosis | 13 | CTNNB1, CTSV, GSTA2, GSTA3, GSTA5, GSTM1, GSTM3, GSTO1, GSTP1, RAC1, RAC2, RAC3, and TXN | 0.00 |
| 18 | Glutathione metabolism | 9 | GSTA2, GSTA3, GSTA5, GSTM1, GSTM3, GSTO1, GSTP1, OPLAH, and PGD | 0.00 |
| 19 | Metabolism of xenobiotics by cytochrome P450 | 7 | GSTA2, GSTA3, GSTA5, GSTM1, GSTM3, GSTO1, and GSTP1 | 0.00 |
| 20 | Chemical carcinogenesis | 7 | GSTA2, GSTA3, GSTA5, GSTM1, GSTM3, GSTO1, and GSTP1 | 0.00 |
| 21 | Fluid shear stress and atherosclerosis | 13 | CTNNB1, CTSV, GSTA2, GSTA3, GSTA5, GSTM1, GSTM3, GSTO1, GSTP1, RAC1, RAC2, RAC3, and TXN | 0.00 |
| 22 | Cell cycle | 7 | SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, and YWHAZ | 0.01 |
| 23 | Oocyte meiosis | 6 | YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, and YWHAZ | 0.02 |
| 24 | Protein processing in endoplasmic reticulum | 8 | GANAB, HSPA1A, HSPA1L, HSPA2, HSPA5, HSPA8, P4HB, and PDIA3 | 0.01 |
| 25 | Endocytosis | 11 | ARF1, ARF3, ARF5, FOLR1, FOLR2, FOLR3, HSPA1A, HSPA1L, HSPA2, HSPA8, and UBB | 0.01 |
| 26 | Hippo signaling pathway | 8 | CDH1, CTNNB1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, and YWHAZ | 0.01 |
| 27 | Antigen processing and presentation | 8 | B2M, CTSV, HSPA1A, HSPA1L, HSPA2, HSPA8, IFI30, and PDIA3 | 0.00 |
| 28 | Estrogen signaling pathway | 4 | HSPA1A, HSPA1L, HSPA2, and HSPA8 | 0.1 |