Table 2.

Evidence for defective bacterial clearance by innate immunity as an early event in the pathogenesis of Crohn’s disease

❑ Genetic polymorphisms in various genes associated with bacterial handling modify the risk for developing Crohn’s disease

❑ Monogenic disorders that affect innate immunity pathways are associated with development of CD-like intestinal inflammation

❑ Defective and delayed acute response to injury in patients with sporadic CD

❑ Protective roles of innate cytokine during acute injury/repair (as opposed to proinflammatory roles in chronic inflammation)

❑ De novo development of IBD-like lesions in patients treated with targeted biological therapies