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. 2021 Nov 18;37(7):1340–1347. doi: 10.1093/ndt/gfab329

Table 4.

Adverse events according to randomized treatment arm

Lower DNa Higher DNa
Adverse event (n = 69) (n = 70)
(No. of participants) (No. of events)
Hypotension (SBP <90 mmHg) 9 (9) 6 (7)
Hypertension (SBP >180 mmHg) 3 (3) 7 (7)
Chest pain/MI 4 (4) 1 (1)
Tachycardia 1 (1) 1 (1)
Diaphoresis 1 (1) 1 (1)
Dyspnea 0 (0) 1 (1)
Cough 2 (3) 0 (0)
Nausea 3 (3) 3 (4)
Abdo/back pain 3 (3) 3 (3)
Bloating 1 (1) 0 (0)
Diarrhea 0 (0) 1 (1)
Perirectal abscess 1 (1) 0 (0)
Cramping 7 (10) 6 (8)
Altered mental status 2 (2) 2 (2)
Headache 0 (0) 2 (3)
Dizziness 1 (1) 0 (0)
Anxiety 2 (2) 0 (0)
Restless legs 1 (1) 0 (0)
Trembling 0 (0) 1 (1)
Itch 1 (1) 1 (1)
Access dysfunction 2 (2) 2 (3)
Other pain 5 (8) 4 (6)
Eye pain 0 (0) 1 (1)

MI, myocardial infarction.