Table 4.

Haplotype analysis of the studied genetic polymorphisms.

Gene	Haplotype		Frequency		p value
			Orthognathic mandible	Mandibular retrognathism
TGFB1	rs4803455-rs1800469	CT	0.264	0.242	0.706
		AT	0.027	0.025	0.930
		CC	0.225	0.213	0.818
		AC	0.482	0.517	0.586
TGFBR2	rs764522-rs3087465	GA	0.084	0.103	0.610
		CA	0.252	0.208	0.407
		GG	0.035	0.049	0.602
		CG	0.627	0.639	0.855

Note: TGFB1: transforming growth factor beta 1; TGFBR2: transforming growth factor beta receptor 2; C: cytosine; A: adenine; T: thymine; G: guanine.