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. 2022 Jun 15;2022:8259135. doi: 10.1155/2022/8259135

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Copyright © 2022 Zhongshi Hong et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

miR-450b-5p overexpression inhibited the malignant behavior of CRC cells in vitro. (a) qRT-PCR analysis showed that miR-450b-5p overexpression in the transfected SW480 and HTC-116 cell lines. (b) The proliferation of SW480 and HCT-116 was determined by MTT assay when miR-450b-5p was increased. (c), (d) The effect of miR-450b-5p on cell cycle and apoptosis was determined by flow cytometry. (e), (f) Ectopic expression of miR-450b-5p inhibited the migration and invasion ability of SW480 and HCT-116 cells, which was detected using transwell assay. Data are represented as mean ± SD of three biological replicates. Compared with mimic NC group, ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^∗∗∗∗P < 0.0001. Scale bar: 10 μm.