Table 3:

Lifetime predicted loss of benefit and harms due to screening delays.

	CRC Incidence per 10,000				Life Years Gained per 10,000		Number of Colonoscopies per 10,000
Scenario	Overall		Late Stage (III or IV)
No screening	23.7		11.6		-------		-------
Guideline concordant, relative to no screening	7.7		2.3		2,727.1		464.4
Change in lifetime outcomes, relative to guideline-concordant screening	Absolute and (Percent) Difference, Relative to Guideline-Concordant Screening
3-month delay in follow-up colonoscopy after an abnormal FIT	0.1	(1.2%)	0.1	(2.6%)	−0.4	(−0.0%)	−4.1	(−0.9%)
3-month delay in receipt of surveillance colonoscopy	0.1	(0.7%)	0.0	(1.1%)	−11.2	(−0.4%)	−6.9	(−1.5%)
6-month delay in receipt of surveillance colonoscopy	0.1	(1.3%)	0.0	(1.1%)	−11.4	(−0.4%)	−12.6	(−2.7%)
1-year delay in return to screening after normal surveillance or follow-up colonoscopy	0.1	(1.2%)	0.1	(2.4%)	−14.1	(−0.5%)	−4.4	(−0.9%)
6-month delay in follow-up colonoscopy after an abnormal FIT	0.2	(2.0%)	0.1	(4.5%)	−31.9	(−1.2%)	−6.4	(−1.4%)
1 year delay in screening initiation	0.3	(3.8%)	0.1	(4.6%)	−44.1	(−1.6%)	−12.5	(−2.7%)
3-month delay in return to FIT screening after a normal FIT	0.7	(8.9%)	0.1	(6.1%)	−59.6	(−2.2%)	−33.5	(−7.2%)
5-year delay in return to screening after normal surveillance or follow-up colonoscopy	0.5	(6.3%)	0.3	(12.1%)	−63.2	(−2.3%)	−20.3	(−4.4%)
Consistent modest delays	1.3	(16.3%)	0.4	(17.9%)	−154.7	(−5.7%)	−58.5	(−12.6%)
6-month delay in return to FIT screening after a normal FIT	1.6	(20.4%)	0.5	(20.2%)	−155.0	(−5.7%)	−70.1	(−15.1%)
5-year delay in screening initiation	1.7	(21.7%)	0.6	(26.8%)	−337.0	(−12.4%)	−65.3	(−14.1%)
Consistent large delays	3.7	(48.6%)	1.5	(64.1%)	−612.3	(−22.5%)	−150.3	(−32.4%)