Table 2.
General characteristics of the included reviews.
| Studies | Diagnosticcriteria | Trials (subjects) |
GERD Classification |
Experimental Intervention | Control Intervention |
Duration | Follow-up period | Quality assessment |
Results summary |
|---|---|---|---|---|---|---|---|---|---|
| Yu [19] | ①, ② | 13 (1089) | NERD, RE | BXD | WM | 4–8 weeks | NA | Cochrane Criteria | BXD was more effective to treat GERD than the optimal combination of WM. |
| Chen [20] | NA | 24 (2002) | NERD, RE | BXD | WM | Unclear | NA | Jada scale | BXD was superior to WM alone in the treatment of GERD, but there was no significant difference in gastroscopy results or on the occurrence of adverse reactions. |
| Dai [21] | 31 (1210) | NERD, RE | BXD | WM | 4 weeks- 8 months | NA | Cochrane Criteria | BXD showed a potential benefit to GERD patients, but further research is needed due to methodological quality and sample size limitations. | |
| Zheng [22] | NA | 11 (1305) | NERD, RE | BXD | WM | 4–8 weeks | NA | Cochrane Criteria | BXD treatment improved total effective and recurrence rates for GERD as compared with those of the control group． |
| Qi [23] | NA | 27 (2300) | NERD, RE | BXD | WM | 4–8 weeks | 3 or 6 months | Cochrane Criteria | The use of BXD tin the treatment of GERD was superior to WM alone in terms of cure rate and total effective rate. |
| Guo [24] | NA | 12 (914) | NERD, RE | BXD | WM | 4–8 weeks | NA | Cochrane Criteria | BXD was superior than conventional WM to treat GERD without inducing severe adverse reactions. |