Table 1.

Inclusion/exclusion criteria

Inclusion criteria	Exclusion criteria
DKD subjects
Signed informed consent	Cause for the impaired kidney function diagnosed primarily to be other than DKD (histologic or clinical)
Age 18–79 years	History of renal transplant
T2DM with clinical diagnosis of DKD and an eGFR of 15–60 mL/min/1.73 m2	Patients with congestive heart failure (NYHA class IV)
UACR ˃3 mg/mmol in the first morning urine sample	Pregnancy
An eGFR decline of <10 mL/min/1.73 m2 over the last 6 months	Any contraindication for MRI examination (e.g. pacemaker, severe claustrophobia)
Stable dose of antidiabetic treatment for >1 month	Allergy to iodine-based contrast agents
BMI 18–35	Involved in the planning or execution of this study
Healthy volunteers
Signed informed consent	HIV/hepatitis B or C positive
Age 18–79 years	Evidence of any active or chronic disease following a detailed medical history including but not limited to T2DM, congestive heart failure (NYHA 3 and 4) and hypertension
eGFR >70 mL/min/1.73 m2	Pregnancy
UACR <3 mg/mmol	Any contraindication for MRI examination (e.g. pacemaker, severe claustrophobia)
BMI 18–35	Allergy to iodine-based contrast agents
Not receiving any medical treatment	Involved in the planning or execution of this study

HIV: human immunodeficiency virus; NYHA: New York Heart Association classification.