Table 1. Comparison of clinical outcomes based on the retrieval or ovulation of DF at the time of retrieval with natural cycle IVF/M treatment.
Variable | A | B | C | P |
No. of patients | 377 | 54 | 34 | |
Age of women, years | 31.2 ± 4.0 | 30.9 ± 3.8 | 31.5 ± 4.1 | 0.803 |
FSH (mIU/mL) | 5.72 ± 2.45 | 6.27 ± 2.55 | 6.23 ± 2.43 | 0.094 |
LH (mIU/mL) | 3.20 ± 2.14 | 2.95 ± 2.33 | 3.09 ± 2.53 | 0.347 |
Estradiol (pg/mL) | 41.59 ± 17.29 | 42.31 ± 21.69 | 41.09 ± 16.81 | 0.982 |
Progesterone (ng/mL) | 0.55 ± 0.35 | 0.49 ± 0.2 | 0.56 ± 0.33 | 0.598 |
No. of oocyte retrieval cycles (%) | 445 (83.0) | 54 (10.1) | 37 (6.9) | |
No. of completed ET cycles | 441 | 52 | 35 | |
No. of oocytes retrieved | 4757 (10.7 ± 5.1) | 501 (9.3 ± 4.7)* | 354 (9.6 ± 5.1) | 0.036 |
No. of oocytes retrieved from DF | 465 (1.0 ± 0.2) | – | – | |
No. of mature oocytes retrieved | 879 (2.0 ± 1.7) | 69 (1.3 ± 1.3)* | 39 (1.1 ± 1.5) * | <0.001 |
No. of immature oocytes retrieved | 3673 (8.3 ± 4.8) | 408 (7.6 ± 4.3) | 298 (8.1 ± 4.3) | 0.528 |
Maturation rate | 63.8 (2345/3673) | 65.4 (267/408) | 64.8 (193/298) | 0.788 |
Fertilization rate | 87.5 (2670/3052) | 84.2 (266/316) | 85.3 (191/224) | 0.178 |
No. of embryos transferred | 1246 (2.8 ± 0.7) | 137 (2.5 ± 1.0)* | 98 (2.7 ± 1.3) | 0.038 |
Clinical pregnancy rate/ET cycle | 34.5 (152/441) | 34.6 (18/52) | 25.7 (9/35) | 0.571 |
Embryo implantation rate | 15.2 (190/1246) | 16.1 (22/137) | 10.2 (10/98) | 0.377 |
Cumulative live birth rate | 69.1 (105/152) | 66.7 (12/18) | 66.7(6/9) | 0.969 |
Singleton | 88 (83.8) | 10 (83.3) | 6 (100.0%) | 0.562 |
Twin | 16 (15.2) | 2 (16.7) | 0 | |
Triplets | 1 (1.0) | 0 | 0 | |
Miscarriage rate/clinical pregnancy | 27.0 (47/152) | 33.3 (6/18) | 33.3 (3/9) | 0.969 |
Values are mean ± SD unless otherwise specified. Abbreviation: DF: dominant follicle. *Significant difference compared with Group A. Abbreviations: No: number; FSH: follicle-stimulating hormone; LH: luteinizing hormone.