Table 4. Comparison of expression level of microRNAs among WHO classification, Masaoka’s stage and CD8, CD68 and CCL18 lowly and highly expressed subgroups determined by immunohistochemistry.

	miR-130b-5p	miR-425-5p	miR-1307-3p	BRRS
WHO classification
A-AB	0.085 (-0.610-0.261)	0.063 (-0.636-0.179)	0.329 (-0.260-0.539)	-1.049 (-1.733-(0.887))
B1-B3	0.056 (-0.388-0.417)	-0.016 (-0.341-0.439)	0.391 (-0.093-0.783)	-1.140 (-1.452-0.700)
C	1.049 (0.775-1.464)	1.217 (0.993-1.342)	1.627 (1.236-1.718)	2.479 (2.266-2.599)
Kruskal-Wallis P	<0.001	<0.001	<0.001	<0.001
B1-B3 vs C adjusted P	<0.001	<0.001	<0.001	<0.001
B1-B3 vs A-AB adjusted P	1.000	0.965	0.800	0.965
C vs A-AB adjusted P	<0.001	<0.001	<0.001	<0.001
Masaoka's stage
I-II	-0.174 (-0.587-0.188)	-0.152 (-0.545-0.132)	0.194 (-0.326-0.466)	-1.271 (-1.646-(-0.916))
III-IV	0.705 (0.314-1.163)	0.752 (0.407-1.217)	1.096 (0.815-1.599)	1.962 (0.707-2.480)
Mann-Whitney P	<0.001	<0.001	<0.001	<0.001
CD8 IHC
Low	0.832 (0.552-1.256)	1.042 (0.618-1.230)	1.316 (0.936-1.633)	2.313 (1.909-2.492)
High	-0.116 (-0.561-0.189)	-0.112 (-0.502-0.179)	0.238 (-0.260-0.565)	-1.233 (-1.605-(-0.887))
Mann-Whitney P	<0.001	<0.001	<0.001	<0.001
CD68 IHC
Low	-0.221 (-0.617-0.155)	-0.183 (-0.545-0.063)	0.139 (-0.326-0.415)	-1.302 (-1.646-(-1.026))
High	0.716 (0.475-1.163)	0.752 (0.407-1.217)	1.096 (0.815-1.599)	1.962 (0.693-2.480)
Mann-Whitney P	<0.001	<0.001	<0.001	<0.001
CCL18 IHC
Low	-0.257 (-0.646-0.111)	-0.277 (-0.564-0.011)	0.054 (-0.362-0.336)	-1.391 (-1.664-(-1.116))
High	0.608 (0.314-1.049)	0.618 (0.280-1.141)	0.936 (0.716-1.485)	1.882 (0.643-2.407)
Mann-Whitney P	<0.001	<0.001	<0.001	<0.001