Table 1. Demographic and clinical characteristics of patients with SCLC.
| Variable | Age groups | |||||||
| Age ≤ 80 year Chemotherapy | Age > 80 year Chemotherapy | |||||||
| Yes n = 37136 (73) | No n = 13805 (27) | Total n = 50941 (100) | P | Yes n = 2774 (43) | No n = 3745 (57) | Total n = 6519 (100) | P | |
| Median age at diagnosis | 64 (58–71) | 68 (61–74) | 65 (59–72) | <0.001 | 82 (81–84) | 83 (81–86) | 83 (81–85) | <0.001 |
| Gender | ||||||||
| Male | 18649 (50.2) | 7002 (50.7) | 25651 (50.4) | 0.314 | 1381 (49.8) | 1686 (45.0) | 3067 (47.0) | <0.001 |
| Female | 18487 (49.8) | 6803 (49.3) | 25290 (49.6) | 1393 (50.2) | 2059 (55.0) | 3452 (53.0) | ||
| Race recode | ||||||||
| White | 32288 (86.9) | 11972 (86.7) | 44260 (86.9) | 0.017 | 2447 (88.2) | 3275 (87.4) | 5722 (87.8) | 0.097 |
| Black | 3376 (9.1) | 1331 (9.6) | 4707 (9.2) | 156 (5.6) | 259 (6.9) | 415 (6.4) | ||
| Other | 1441 (3.9) | 483 (3.5) | 1924 (3.8) | 170 (6.1) | 207 (5.5) | 377 (5.8) | ||
| Unknown | 31 (0.1) | 19 (0.1) | 50 (0.1) | 1 (0.0) | 4 (0.1) | 5 (0.1) | ||
| CHSDA region | ||||||||
| EAST | 19175 (51.6) | 6678 (48.4) | 25853 (50.8) | <0.001 | 1210 (43.6) | 1501 (40.1) | 2711 (41.6) | <0.001 |
| NORTHWEST | 81 (0.2) | 15 (0.1) | 96 (0.2) | 3 (0.1) | 2 (0.1) | 5 (0.1) | ||
| SOUTHWEST | 12904 (34.7) | 5704 (41.3) | 18608 (36.5) | 1162 (41.9) | 1779 (47.5) | 2941 (45.1) | ||
| NORTH | 4976 (13.4) | 1408 (10.2) | 6384(12.5) | 399 (14.4) | 463 (12.4) | 862 (13.2) | ||
| Year of diagnosis | ||||||||
| 2004–2007 | 12499 (33.7) | 4796 (34.7) | 17295 (34.0) | 0.013 | 907 (32.7) | 1164 (31.1) | 2071 (31.8) | 0.097 |
| 2008–2011 | 12264 (33.0) | 4587 (33.2) | 16851 (33.1) | 991 (35.7) | 1305 (34.8) | 2296 (35.2) | ||
| 2012–2017 | 12373 (33.3) | 4422 (32.0) | 16795 (33.0) | 876 (31.6) | 1276 (34.1) | 2152 (33.0) | ||
| Primary Site | ||||||||
| Upper lobe | 17512 (47.2) | 5866 (42.5) | 23378 (45.9) | <0.001 | 1188 (42.8) | 1403 (37.5) | 2591 (39.7) | <0.001 |
| Middle lobe | 1431 (3.9) | 514 (3.7) | 1945 (3.8) | 118 (4.3) | 159 (4.2) | 277 (4.2) | ||
| Lower lobe | 6941 (18.7) | 2522 (18.3) | 9463 (18.6) | 690 (24.9) | 851 (22.7) | 1541 (23.6) | ||
| NOS | 6301 (17.0) | 3173 (23.0) | 9474 (18.6) | 482 (17.4) | 939 (25.1) | 1421 (21.8) | ||
| Overlapping lesion | 559 (1.5) | 226 (1.6) | 785 (1.5) | 54 (1.9) | 51 (1.4) | 105 (1.6) | ||
| Main bronchus | 4392 (11.8) | 1504 (10.9) | 5896 (11.6) | 242 (8.7) | 342 (9.1) | 584 (9.0) | ||
| Grade | ||||||||
| I | 53 (0.1) | 29 (0.2) | 82 (0.2) | 0.019 | 0 (0.0) | 7 (0.2) | 7 (0.1) | 0.027 |
| II | 116 (0.3) | 57 (0.4) | 173 (0.3) | 6 (0.2) | 12 (0.3) | 18 (0.3) | ||
| III | 3239 (8.7) | 1224 (8.9) | 4463 (8.8) | 221 (8.0) | 303 (8.1) | 524 (8.0) | ||
| IV | 6948 (18.7) | 2449 (17.7) | 9397 (18.4) | 556 (20.0) | 666 (17.8) | 1222 (18.7) | ||
| Unknown | 26780 (72.1) | 10046 (72.8) | 36826 (72.3) | 1991 (71.8) | 2757 (73.6) | 4748 (72.8) | ||
| Laterality | ||||||||
| Right-origin of primary | 20451 (55.1) | 7137 (51.7) | 27588 (54.2) | <0.001 | 1528 (55.1) | 1996 (53.3) | 3524 (54.1) | <0.001 |
| Left-origin of primary | 14731 (39.7) | 5385 (39.0) | 20116 (39.5) | 1096 (39.5) | 1407 (37.6) | 2503 (38.4) | ||
| Paired sit | 1375 (3.7) | 931 (6.7) | 2306 (4.5) | 104 (3.7) | 253 (6.8) | 357 (5.5) | ||
| Only one side - side unspecified | 161 (0.4) | 101 (0.7) | 262 (0.5) | 8 (0.3) | 27 (0.7) | 35 (0.5) | ||
| Not a paired site | 79 (0.2) | 29 (0.2) | 108 (0.2) | 8 (0.3) | 8 (0.2) | 16 (0.2) | ||
| Bilateral single primary | 339 (0.9) | 222 (1.6) | 561 (1.1) | 30 (1.1) | 54 (1.4) | 84 (1.3) | ||
| Stage Group | ||||||||
| I | 1416 (3.8) | 597 (4.3) | 2013 (4.0) | <0.001 | 156 (5.6) | 207 (5.5) | 363 (5.6) | <0.001 |
| II | 842 (2.3) | 182 (1.3) | 1024 (2.0) | 61 (2.2) | 56 (1.5) | 117 (1.8) | ||
| III | 11795 (31.8) | 2880 (20.9) | 14675 (28.8) | 884 (31.9) | 1022 (27.3) | 1906 (29.2) | ||
| IV | 23083 (62.2) | 10146 (73.5) | 33229 (65.2) | 1673 (60.3) | 2460 (65.7) | 4133 (63.4) | ||
| Radiation recode | ||||||||
| Yes | 22007 (59.3) | 2890 (20.9) | 24897 (48.9) | <0.001 | 1073 (38.7) | 594 (15.9) | 1667 (25.6) | <0.001 |
| No | 15129 (40.7) | 10915 (79.1) | 26044 (51.1) | 1701 (61.3) | 3151 (84.1) | 4852 (74.4) | ||
| Surgery | ||||||||
| Yes | 1117 (3.0) | 512 (3.7) | 1629 (3.2) | <0.001 | 39 (1.4) | 94 (2.5) | 133 (2.0) | 0.002 |
| No | 36019 (97.0) | 13293 (96.3) | 49312 (96.8) | 2735 (98.6) | 3651 (97.5) | 6386 (98.0) | ||
| Marital status | ||||||||
| Married | 19567 (52.7) | 6015 (43.6) | 25582 (50.2) | <0.001 | 1257 (45.3) | 1356 (36.2) | 2613 (40.1) | <0.001 |
| Single | 5024 (13.5) | 2386 (17.3) | 7410 (14.5) | 162 (5.8) | 255 (6.8) | 417 (6.4) | ||
| Divorced | 5777 (15.6) | 2060 (14.9) | 7837 (15.4) | 186 (6.7) | 258 (6.9) | 444 (6.8) | ||
| Windowed | 5001 (13.5) | 2505 (18.1) | 7506 (14.7) | 1073 (38.7) | 1689 (45.1) | 2762 (42.4) | ||
| Unknown | 1211 (3.3) | 630 (4.6) | 1841 (3.6) | 86 (3.1) | 166 (4.4) | 252 (3.9) | ||
| Unmarried or domestic partner | 65 (0.2) | 16 (0.1) | 81 (0.2) | 0 (0.0) | 2 (0.1) | 2 (0.0) | ||
| Separated | 491 (1.3) | 193 (1.4) | 684 (1.3) | 10 (0.4) | 19 (0.5) | 29 (0.4) | ||
| High school education | ||||||||
| >21 | 6990 (18.8) | 3338 (24.2) | 10328 (20.3) | <0.001 | 445 (16.0) | 730 (19.5) | 1175 (18.0) | <0.001 |
| 13–20 | 11319 (30.5) | 4366 (31.6) | 15685 (30.8) | 790 (28.5) | 1103 (29.5) | 1893 (29.0) | ||
| 7–12 | 16421 (44.2) | 5385 (39.0) | 21806 (42.8) | 1320 (47.6) | 1611 (43.0) | 2931 (45.0) | ||
| ≤7 | 2406 (6.5) | 716 (5.2) | 3122 (6.1) | 219 (7.9) | 301 (8.0) | 520 (8.0) | ||
| Median household income | ||||||||
| ≤38000 | 3626 (9.8) | 1440 (10.4) | 5066 (9.9) | 0.001 | 126 (4.5) | 208 (5.6) | 334 (5.1) | 0.051 |
| 38000–47999 | 7513 (20.2) | 2792 (20.2) | 10305 (20.2) | 452 (16.3) | 590 (15.8) | 1042 (16.0) | ||
| 48000–62999 | 14408 (38.8) | 5489 (39.8) | 19897 (39.1) | 1062 (38.3) | 1511 (40.3) | 2573 (39.5) | ||
| >63000 | 11589 (31.2) | 4084 (29.6) | 15673 (30.8) | 1134 (40.9) | 1436 (38.3) | 2570 (39.4) | ||
Abbreviations: SCLC: Small cell lung cancer; NOS: Not otherwise specified.