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. 2022 Jun 10;14(11):4699–4713. doi: 10.18632/aging.203474

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Copyright: © 2022 You et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Circ_0063804 silencing promoted OC cells apoptosis and weakened proliferation and resistance to cisplatin. (A) Circ_0063804 expression in OC cells was successfully regulated via transfection. (B, C) According to CCK-8 assay and colony formation assay, circ_0063804 silencing inhibited OC cells proliferation, and circ_0063804 overexpression promoted OC cells proliferation. (D) Flow cytometry revealed that circ_0063804 silencing promoted OC cells apoptosis, and circ_0063804 overexpression inhibited OC cells apoptosis. (E) MTT assay indicated that circ_0063804 silencing reduced the IC50 of OC cells, and circ_0063804 overexpression elevated the IC50 of OC cells. (F) Circ_0063804 silencing reduced OC cells resistance to cisplatin, and circ_0063804 overexpression enhanced OC cells resistance to cisplatin. ** P < 0.01. CCK-8: cell counting kit-8. MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. OC: ovarian cancer.