Table 1.
:Baseline adjusted values for blood plasma nicotine pharmacokinetic assessments in adult traditional tobacco product users following use of a single nicotine pouch or cigarette product. Cmax maximum observed plasma concentration, AUCt area under the plasma concentration–time curve from time 0 to the time of the last sampling timepoint, Tmax time to Cmax, T1/2 terminal elimination half-life, AUC0–90 AUC from timepoint 0–90 min, AUC0–inf AUC from timepoint 0 to infinity, Clast observed plasma concentration at the last sampling timepoint
| Assessment (unit) | Nicotine pouch #2 | Nicotine pouch #3 | Cigarette | |
|---|---|---|---|---|
| n | 21 | 22 | 22 | |
| Cmax (ng/ml) | Mean (SD) | 5.154 (1.662) | 7.856 (2.451) | 11.60 (5.171) |
| Median (min, max) | 5.060 (2.66, 9.43) | 6.983 (4.39, 13.5) | 9.868 (4.56, 23.1) | |
| AUCt (h*ng/ml) | Mean (SD) | 12.23 (4.996) | 18.35 (8.180) | 19.60 (10.75) |
| Median (min, max) | 11.05 (6.32, 26.1) | 16.95 (8.86, 45.5) | 18.24 (8.26, 54.7) | |
| Tmax (min) | Mean (SD) | 26.43 (9.468) | 22.092 (8.478) | 8.544 (6.552) |
| Median (min, max) | 30 (7.98, 45) | 19.98 (7.02, 31.02) | 7.002 (4.998, 34.02) | |
| T1/2(z) (min) | Mean (SD) | 159.36 (57.006) | 146.22 (52.656) | 151.74 (51.63) |
| Median (min, max) | 150.36 (86.4, 319.2) | 135.06 (103.8, 343.2) | 140.1 (101.4, 360.6) | |
| AUC0–90 (h*ng/ml) | Mean (SD) | 5.185 (1.611) | 7.876 (2.316) | 8.829 (4.012) |
| Median (min, max) | 4.705 (2.70, 9.80) | 7.248 (4.81, 13.1) | 8.141 (3.93, 19.1) | |
| AUC0–inf (h*ng/ml) | Mean (SD) | 14.90 (6.984) | 21.51 (11.27) | 23.16 (16.52) |
| Median (min, max) | 13.57 (7.91, 37.7) | 18.95 (11.3, 65.6) | 20.08 (9.35, 87.1) | |
| Clast (ng/ml) | Mean (SD) | 0.6480 (0.2768) | 0.8084 (0.4032) | 0.7670 (0.7122) |
| Median (min, max) | 0.5670 (0.401, 1.61) | 0.7221 (0.405, 2.44) | 0.5717 (0.292, 3.74) |