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. 2022 Jun 8;606(7915):812–819. doi: 10.1038/s41586-022-04803-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — Repli-seq was averaged for each of the 16 fractions in a +/− 750 kb window at (a) Boundary class 1, dot boundaries with complex CTCF motif orientation, (b) Boundary class 4, dotless boundaries with complex CTCF motif orientation, and (c) Boundary class 6, dotless boundaries with no CTCF, further stratified by colocalization with transcribed genes (+ transcription) vs. no genes & no transcribed genes (- transcription) within +/− 100 kb of the midpoint of the boundary. 16 Fraction Repli-seq images pileup scale 0.6–1.85. Boundary numbers provided in figure for autosomal chromosomes only.