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. 2022 Jun 15;606(7915):718–724. doi: 10.1038/s41586-022-04800-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Overlayed length distributions of reads mapping against the CO92 Y. pestis reference genome, calculated for the entire dataset (gray) as well as for 117 regions surrounding putatively contaminant SNPs (blue). Regions were extracted within a 150 bp window surrounding each putatively contaminant SNP. Dotted lines represent average fragment lengths for the entire dataset and for the 117 putatively contaminant SNP regions in gray and blue, respectively. Reads comprising contaminant SNP regions show a distinct length distribution compared to the one observed across the entire BSK001/003 genome, with a marked shift towards longer read lengths. The 76 bp fragment length peak represents the uppermost possible read length of single-end sequenced reads, which comprised the majority of data within the present dataset. Ancient DNA damage patterns were compared between the entire dataset (upper panel) and the putatively contaminant SNP regions (lower panel), showing a near 3-fold reduction in the latter as estimated for the terminal 5′ base.