Table 2.

Gene-CVRF score interaction results in GWAS: Top ten genes interacted with the CVRF score to modify AD risk, sorted by meta-analysis p value

Gene	Chr	pROSMAP	pWHICAP AA	pWHICAP Whites	pCH	pNACC	pMeta	pFDR
FMNL2	2	0.001	0.189	0.038	0.009	0.012	6.59 × 10–7	0.012
LOC401357	7	0.172	0.362	0.020	0.001	0.006	1.13 × 10–6	0.012
AMMECR1L	2	0.940	0.073	0.044	0.005	0.001	2.43 × 10–6	0.017
CFAP99	4	0.549	0.937	0.424	4.1 × 10–4	0.002	1.27 × 10–5	0.068
SLC22A14	3	0.294	0.425	0.307	0.293	4.90 × 10–5	1.81 × 10–5	0.070
PRG3	11	0.387	0.090	0.012	0.205	0.001	1.96 × 10–5	0.070
PTPRF	1	0.056	0.563	0.532	0.659	3.10 × 10–5	2.84 × 10–5	0.087
PLA2G4E	15	0.254	0.893	0.219	0.509	3.20 × 10–5	4.55 × 10–5	0.095
ACACB	12	NA	0.184	0.135	0.038	0.004	4.98 × 10–5	0.095
LINC00353	13	0.004	0.270	0.267	0.106	0.014	5.29 × 10–5	0.095

p_cohort p value of the gene-CVRF score interaction test in each cohort, AA African–Americans, CH WHICAP and EFIGA Caribbean Hispanics, p_Meta p value of the meta-analyzed gene-CVRF score interaction results from five cohorts, p_FDR FDR adjusted p value of the meta-analysis p value, NA not available