Table 3.
Association of FMNL2 expression with pathologic diagnosis of AD using the multi-region brain transcriptomes from three cohorts
| Cohort | Brain region | n | b | SE | p |
|---|---|---|---|---|---|
| ROSMAP | Dorsolateral prefrontal cortex (DLPFC) | 1092 | 0.582 | 0.200 | 0.004 |
| Posterior cingulate cortex (PCC) | 661 | 1.040 | 0.316 | 0.001 | |
| Anterior caudate (AC) | 731 | 0.875 | 0.350 | 0.012 | |
| MSBB | Frontal pole (MB10) | 214 | 0.369 | 0.623 | 0.554 |
| Superior temporal gyrus (BM22) | 191 | 1.038 | 0.718 | 0.149 | |
| Parahippocampal gyrus (BM36) | 161 | 2.970 | 0.833 | 0.0004 | |
| Inferior frontal gyrus (BM44) | 186 | 1.235 | 0.652 | 0.058 | |
| Mayo | Temporal cortex (TCX) | 261 | 1.204 | 0.473 | 0.011 |
| Cerebellum (CBE) | 262 | − 0.348 | 0.642 | 0.588 |
n sample size, b estimate, SE standard error, p p value