. 2022 Jun 22;12:10603. doi: 10.1038/s41598-022-14795-6

Table 1.

Distribution of genotypes and alleles of the g.117803515 C > T—NOS1 (rs1879417), c.1823 C > T (p.Ser608Leu)—NOS2 (rs2297518), c.47 C > T—SOD2 (rs4880), c.-89 A > T—CAT (rs7943316), c.660 T > C—GPX4 (rs713041) and ORs with 95% Cis in patients with MS and healthy volunteers.

Genotype/allele	Control (n = 140)		MS (n = 142)		Crude OR (95% CI)*	p	Adjusted OR (95% CI)*	p
Genotype/allele	Number	Frequency	Number	Frequency	Crude OR (95% CI)*	p	Adjusted OR (95% CI)*	p
g.117803515 C > T—*NOS1* (rs1879417)
C/C	23	0.164	35	0.246	1.664 (0.924–2.995)	0.090	1.753 (0.967–3.176)	0.064
C/T	78	0.557	70	0.493	0.773 (0.484–1.235)	0.281	0.760 (0.474–1.218)	0.254
T/T	39	0.279	37	0.261	0.913 (0.539–1.545)	0.733	0.895 (0.527–1.521)	0.683
χ² = 1.505; p = 0.220
C	124	0.443	140	0.493	1.238 (0.879–1.743)	0.221	1.270 (0.899–1.795)	0.175
T	156	0.557	144	0.507	0.808 (0.574–1.137)	0.221	0.787 (0.557–1.112)	0.175
c.1823C > T (p.Ser608Leu)—*NOS2* (rs2297518)
C/C	60	0.429	99	0.697	3.070 (1.880–5.011)	< 0.001^0.996	3.131 (1.909–5.135)	< 0.001^0.996
C/T	48	0.343	29	0.204	0.492 (0.288–0.841)	0.010^0.740	0.488 (0.285–0.839)	0.009^0.748
T/T	32	0.229	14	0.099	0.369 (0.187–0.727)	0.004^0.836	0.361 (0.182–0.715)	0.003^0.849
χ² = 20.294; p < 0.001
C	168	0.600	227	0.799	2.101 (1.501–2.941)	< 0.001^0.982	2.131 (1.518–2.992)	< 0.001^0.985
T	112	0.400	57	0.201	0.476 (0.340–0.666)	< 0.001^0.982	0.469 (0.334–0.659)	< 0.001^0.985
c.47 C > T (p.Val16Ala)—*SOD2* (rs4880)
C/C	38	0.271	23	0.162	0.519 (0.290–0.928)	0.027^0.600	0.484 (0.268–0.874)	0.016^0.678
T/C	74	0.529	83	0.585	1.255 (0.784–2.009)	0.345	1.240 (0.772–1.991)	0.374
T/T	28	0.200	36	0.254	1.358 (0.775–2.380)	0.284	1.474 (0.833–2.609)	0.183
χ² = 4.250; p = 0.039
C	150	0.536	129	0.454	0.689 (0.483–0.985)	0.041^0.595	0.647 (0.449–0.932)	0.019^0.729
T	130	0.464	155	0.546	1.451 (1.015–2.072)	0.041^0.595	1.546 (1.073–2.227)	0.019^0.730
c.-89 A > T—*CAT* (rs7943316)
A/A	24	0.171	13	0.092	0.487 (0.237–1.001)	0.050	0.500 (0.242–1.031)	0.060
A/T	97	0.693	118	0.831	2.180 (1.236–3.843)	0.007^0.774	2.200 (1.243–3.894)	0.007^0.783
T/T	19	0.136	11	0.077	0.535 (0.244–1.170)	0.117	0.508 (0.230–1.119)	0.093
χ² = 0.139; p = 0.709
A	145	0.518	144	0.507	0.913 (0.565–1.475)	0.709	0.942 (0.581–1.528)	0.809
T	135	0.482	140	0.493	1.096 (0.678–1.771)	0.709	1.062 (0.654–1.722)	0.809
c.660 T > C—*GPX4* (rs713041)
C/C	57	0.407	39	0.275	0.551 (0.335–0.909)	0.019^0.648	0.548 (0.331–0.906)	0.019^0.656
T/C	65	0.464	72	0.507	1.187 (0.744–1.894)	0.473	1.215 (0.759–1.947)	0.417
T/T	18	0.129	31	0.218	1.893 (1.003–3.573)	0.049^0.505	1.838 (0.970–3.481)	0.062^0.466
χ² = 7.223; p = 0.007
C	179	0.639	150	0.528	0.628 (0.445–0.886)	0.008^0.773	0.632 (0.447–0.893)	0.009^0.762
T	101	0.361	134	0.472	1.592 (1.129–2.246)	0.008^0.773	1.583 (1.120–2.237)	0.009^0.762

p-values were obtained from logistic regression analyses with the codominant, dominant and recessive models without Bonferroni correction. p < 0.05 along with corresponding ORs are bold and in bold (for the genotypes/alleles contributing to the MS development) or in italics (for the genotypes/alleles with a protective effect); *OR adjusted for gender. Statistical power (1 − β) for significant comparisons is given in superscripts.