Table 4.
Distribution of genotypes and alleles of the g.117803515 C > T—NOS1 (rs1879417), c.1823 C > T (p.Ser608Leu)—NOS2 (rs2297518), c.47 C > T—SOD2 (rs4880), c.-89 A > T—CAT (rs7943316), c.660 T > C—GPX4 (rs713041) and Ors with 95% Cis in men and women with MS.
| Genotype/allele | Men (n = 118) | Women (n = 164) | ||||||
|---|---|---|---|---|---|---|---|---|
| Control (n = 51) | MS (n = 67) | Crude OR (95% CI)* | p | Control (n = 89) | MS (n = 75) | Crude OR (95% CI)* | p | |
| N (freq.) | N (freq.) | N (freq.) | N (freq.) | |||||
| c.-420-34221G > A—NOS1 (rs1879417) | ||||||||
| G/G | 6 (0.118) | 14 (0.209) | 1.981 (0.703–5.580) | 0.196 | 17 (0.191) | 21 (0.280) | 1.647 (0.793–3.419) | 0.181 |
| G/A | 27 (0.529) | 37 (0.552) | 1.096 (0.528–2.277) | 0.805 | 51 (0.573) | 33 (0.440) | 0.585 (0.315–1.088) | 0.090 |
| A/A | 18 (0.353) | 16 (0.239) | 0.575 (0.258–1.284) | 0.177 | 21 (0.236) | 21 (0.280) | 1.259 (0.624–2.542) | 0.520 |
| χ2 = 2.786; p = 0.095 | χ2 = 0.169; p = 0.681 | |||||||
| G | 39 (0.382) | 65 (0.485) | 1.605 (0.913–2.819) | 0.100 | 85 (0.478) | 75 (0.500) | 1.097 (0.706–1.704) | 0.681 |
| A | 63 (0.618) | 69 (0.515) | 0.623 (0.355–1.095) | 0.100 | 93 (0.522) | 75 (0.500) | 0.912 (0.587–1.417) | 0.681 |
| c.1823C > T (p.Ser608Leu)—NOS2 (rs2297518) | ||||||||
| C/C | 18 (0.353) | 48 (0.716) | 4.632 (2.118–10.127) | < 0.0010.978 | 42 (0.472) | 51 (0.680) | 2.378 (1.255–4.506) | 0.0080.767 |
| C/T | 18 (0.353) | 14 (0.209) | 0.484 (0.213–1.102) | 0.084 | 30 (0.337) | 15 (0.200) | 0.402 (0.240–1.007) | 0.052 |
| T/T | 15 (0.294) | 5 (0.075) | 0.194 (0.065–0.577) | 0.0030.855 | 17 (0.191) | 9 (0.120) | 0.578 (0.241–1.384) | 0.218 |
| χ2 = 17.534; p < 0.001 | χ2 = 5.804; p = 0.016 | |||||||
| C | 54 (0.529) | 110 (0.821) | 2.958 (1.716–5.100) | < 0.0010.774 | 114 (0.640) | 117 (0.780) | 1.683 (1.090–2.598) | 0.0190.326 |
| T | 48 (0.471) | 24 (0.179) | 0.338 (0.196–0.583) | < 0.0010.774 | 64 (0.360) | 33 (0.220) | 0.594 (0.385–0.917) | 0.0190.327 |
| c.47C > T (p.Val16Ala)—SOD2 (rs4880) | ||||||||
| C/C | 16 (0.314) | 15 (0.224) | 0.631 (0.277–1.439) | 0.274 | 22 (0.247) | 8 (0.107) | 0.364 (0.151–0.840) | 0.0240.640 |
| T/C | 27 (0.529) | 41 (0.612) | 1.402 (0.671–2.930) | 0.369 | 47 (0.528) | 42 (0.560) | 1.137 (0.613–2.109) | 0.683 |
| T/T | 8 (0.157) | 11 (0.164) | 1.056 (0.391–2.852) | 0.915 | 20 (0.225) | 25 (0.333) | 1.725 (0.864–3.444) | 0.122 |
| χ2 = 0.663; p = 0.415 | χ2 = 5.707; p = 0.017 | |||||||
| C | 59 (0.578) | 71 (0.530) | 0.790 (0.446–1.397) | 0.417 | 91 (0.511) | 58 (0.387) | 0.565 (0.350–0.911) | 0.0190.434 |
| T | 43 (0.422) | 63 (0.470) | 1.267 (0.716–2.242) | 0.417 | 87 (0.489) | 92 (0.613) | 1.769 (1.097–2.853) | 0.0190.434 |
| c.-89 A > T—CAT (rs7943316) | ||||||||
| A/A | 7 (0.137) | 6 (0.090) | 0.618 (0.194–1.967) | 0.415 | 17 (0.191) | 7 (0.093) | 0.436 (0.170–1.117) | 0.084 |
| A/T | 34 (0.667) | 56 (0.836) | 2.545 (1.066–6.075) | 0.0350.553 | 63 (0.708) | 62 (0.827) | 1.968 (0.927–4.177) | 0.078 |
| T/T | 10 (0.196) | 5 (0.075) | 0.331 (0.105–1.038) | 0.058 | 9 (0.101) | 6 (0.080) | 0.773 (0.262–2.281) | 0.641 |
| χ2 = 0.667; p = 0.414 | χ2 = 1.021; p = 0.312 | |||||||
| A | 48 (0.471) | 68 (0.507) | 1.368 (0.642–2.916) | 0.417 | 97 (0.545) | 76 (0.507) | 0.719 (0.378–1.369) | 0.316 |
| T | 54 (0.529) | 66 (0.493) | 0.713 (0.343–1.558) | 0.417 | 81 (0.455) | 74 (0.493) | 1.390 (0.731–2.644) | 0.316 |
| c.660 T > C—GPX4 (rs713041) | ||||||||
| C/C | 23 (0.451) | 17 (0.254) | 0.414 (0.190–0.902) | 0.0260.605 | 34 (0.382) | 22 (0.293) | 0.671 (0.349–1.294) | 0.234 |
| T/C | 21 (0.412) | 33 (0.493) | 1.387 (0.665–2.892) | 0.384 | 44 (0.494) | 39 (0.520) | 1.108 (0.599–2.049) | 0.744 |
| T/T | 7 (0.137) | 17 (0.254) | 2.137 (0.811–5.632) | 0.124 | 11 (0.124) | 14 (0.187) | 1.627 (0.690–3.837) | 0.266 |
| χ2 = 5.548; p = 0.019 | χ2 = 2.052; p = 0.152 | |||||||
| C | 67 (0.657) | 67 (0.500) | 0.537 (0.316–0.913) | 0.0220.375 | 112 (0.629) | 83 (0.553) | 0.716 (0.453–1.134) | 0.155 |
| T | 35 (0.343) | 67 (0.500) | 1.862 (1.095–3.167) | 0.0220.375 | 66 (0.371) | 67 (0.447) | 1.396 (0.882–2.209) | 0.155 |
p < 0.05 along with corresponding ORs are bold and in bold (for the genotypes/alleles contributing to the MS development) or in italics (for the genotypes/alleles with a protective effect); *OR adjusted for gender. Statistical power (1 − β) for significant comparisons is given in superscripts.