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. 2022 Jun 22;12:10581. doi: 10.1038/s41598-022-14241-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of Rhodiola rosea on the fecal microbiome of db/db mice. Bray–Curtis principal coordinate ordination of the data from Supplemental Fig. 1. The corresponding PERMANOVA (Table 1) identifies significant differences in microbiota composition with treatment and time. The number of fecal samples from different mice analyzed is n = 5 (R. rosea week 6), n = 7 (R. rosea week 7), n = 6 (R. rosea week 8), n = 6 (R. rosea week 12), n = 8 (water week 6), n = 2 (water week 7), n = 4 (water week 8), and n = 4 (water week 12).