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. 2022 Jun 22;12:10581. doi: 10.1038/s41598-022-14241-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Rhodiola rosea treatment reduces circulating LPS and hepatocyte CRP expression. At 14 weeks of age, mice were sacrificed and serum and liver tissue obtained. (a) Serum LPS levels, measured by the LAL assay (n = 8 for water-treated and n = 6 for R. rosea-treated mice). **P < 0.01, Mann–Whitney U test. (b) Relative expression of CRP transcripts in mouse liver, calculated by the ΔΔCt method (n = 6 for water-treated and n = 5 for R. rosea-treated mice). *P < 0.05, one sample Wilcoxon test.