Table 2.
CSF biomarkers in DM1 participants
| Samples | Aβ 1-42 (pg/mL) | Aβ 1-40 (pg/mL) | Aβ 1-42/Aβ 1-40 Ratio (%) | Total-Tau (pg/mL) | Phospho-Tau (pg/mL) |
|---|---|---|---|---|---|
| #3 | 675 | 9897 | 6.8% | 444 | 61.3 |
| #4 | 1158 | 11,874 | 9.8% | 283 | 53.4 |
| #6 | N/A | N/A | N/A | N/A | N/A |
| #7 | 510 | 5742 | 8.9% | 135 | 21.7 |
| #8 | 762 | 9136 | 8.3% | 244 | 38.8 |
| #10 | 635 | 7298 | 8.7% | 111 | 20.1 |
| #12 | 496 | 5744 | 8.6% | 281 | 24.2 |
| #13 | N/A | N/A | N/A | N/A | N/A |
| #14 | N/A | N/A | N/A | N/A | N/A |
| #15 | 335 | 4463 | 7.5% | 115 | 17.4 |
| #17 | 694 | 7823 | 8.9% | 114 | 19.5 |
| #19 | 223 | 8148 | 2.7% | 581 | 92.8 |
| Mean | 609.78 | 7791.67 | 8% | 256.44 | 38.80 |
| Median | 635.00 | 7823.00 | 9% | 244.00 | 24.20 |
| SD | 270.12 | 2311.68 | 2% | 165.14 | 25.79 |
| 1st quartile | 496.00 | 5744.00 | 8% | 115.00 | 20.10 |
| Last quartile | 694.00 | 8148.00 | 9% | 281.00 | 38.80 |
Standard CSF cut-offs provided by the manufacturer for distinguishing Alzheimer’s disease from other dementia and controls are 56.6 pg/mL for phospho-Tau, 400 pg/mL for total-Tau, 600 pg/mL for Aβ 1-42 and 6.9% for Aβ 1-42/Aβ 1-40 ratio