Table 3.
Plasma biomarkers in DM1 participants
| Participant samples | GFAP (pg/mL) | NF-L (pg/mL) | TAU (pg/mL) | Aβ 1-42 (pg/mL) | Aβ 1-40 (pg/mL) | Aβ 1-42/Aβ 1-40 Ratio |
|---|---|---|---|---|---|---|
| #3 | 99.75 | 39.08 | 3.78 | 51.6 | 242.7 | 0.213 |
| #4 | 70.43 | 15.54 | 0.47 | 48.3 | 198.0 | 0.244 |
| #6 | 61.42 | 20.84 | 1.40 | 58.5 | 267.3 | 0.219 |
| #7 | 52.15 | 13.69 | 2.63 | 16.2 | 260.7 | 0.062 |
| #8 | 92.61 | 12.80 | 2.89 | 42.6 | 173.1 | 0.246 |
| #10 | 113.05 | 14.77 | 0.84 | 54.0 | 212.1 | 0.255 |
| #12 | N/A | N/A | N/A | 49.5 | 193.5 | 0.256 |
| #13 | 48.50 | 4.86 | 1.08 | 31.2 | 160.8 | 0.194 |
| #14 | 122.42 | 20.18 | 3.12 | 42.0 | 188.1 | 0.223 |
| #15 | 81.50 | 5.70 | 1.56 | 23.1 | 204.0 | 0.113 |
| #17 | 106.17 | 8.72 | 1.60 | 34.5 | 192.9 | 0.179 |
| #19 | 91.99 | 100.86 | 1.95 | 46.5 | 216.6 | 0.215 |
| Mean | 85.45 | 23.37 | 1.94 | 41.50 | 209.15 | 0.20 |
| Median | 91.99 | 14.77 | 1.60 | 44.55 | 201.00 | 0.22 |
| SD | 24.80 | 27.35 | 1.04 | 12.85 | 32.99 | 0.06 |
| 1st quartile | 65.92 | 10.76 | 1.24 | 33.68 | 191.70 | 0.19 |
| Last quartile | 99.39 | 20.51 | 2.29 | 48.60 | 213.23 | 0.24 |
For reference, median plasma values of ten healthy donors indicated in the data sheet of the kit were: 8.58 pg/mL for Nf-L, 64.2 pg/mL for GFAP and 2.31 pg/mL for total-Tau, respectively