Table 1.
Characteristics of study population (n = 94)
| Characteristics of study population (n = 94) | ||
|---|---|---|
| Serum concentrations, n | 94 | |
| Patients, n | 74 | |
| Gender, n (%) | ||
| Male | 88 | (93.6) |
| Female | 6 | (6.4) |
| Age (years), n = 93, mean ± SD (min–max) | 11.6 ± 3.3 | (6–21) |
| Weight (kg), n = 78, mean ± SD (min–max) | 45.4 ± 18.8 | (21.6–91.2) |
| Nicotine abuse, n (%) | 3 | (3,2) |
| Oral contraception, n (%) | 0 | (0) |
| Dose (mg/day), n = 82, mean ± SD (min–max) | 42.9 ± 18.6 | (10–80) |
| Weight-normalized dose (mg/(kg x day)), n = 76, mean ± SD (min–max) | 1.0 ± 0.3 | (0.3–2.1) |
| Patients with ICD-10 Diagnosis, n (%) | 44 | |
| Attention deficit hyperactivity disorder, predominantly inattentive type (F90.0) | 18 | (41) |
| Attention deficit hyperactivity disorder, predominantly hyperactive type (F90.1) | 22 | (50) |
| Combined vocal and multiple motor tic disorder (F95.2) | 3 | (7) |
| Overactive disorder associated with mental retardation and stereotyped movements | 1 | (2) |
| Patients with comorbidities, n (%) | 16 | |
| One comorbidity | 11 | (68.8) |
| More than one comorbidity | 5 | (31.2) |
| Comorbidities, n, multiple entries | ||
| Undifferentiated schizophrenia (F20.3) | 1 | |
| Major depressive disorder, moderate (F32.1) | 1 | |
| Adjustment disorders (F43.2) | 1 | |
| Anorexia nervosa (F50.0) | 1 | |
| Sleep terrors (F51.4) | 1 | |
| Other developmental disorders of speech and language (F80.8) | 1 | |
| Specific reading disorder (F81.0) | 3 | |
| Mixed disorder of scholastic skills (F81.3) | 1 | |
| Specific developmental disorder of motor function (F82.9) | 1 | |
| Atypical autistic disorder (F84.1) | 1 | |
| Asperger’s syndrome (F84.5) | 1 | |
| Other mixed disorders of conduct and emotions (F92.8) | 3 | |
| Other childhood emotional disorders (F93.8) | 2 | |
| Childhood emotional disorder, unspecified (F93.9) | 1 | |
| Enuresis not due to a substance or known physiological condition (F98.0) | 1 | |
| Encopresis not due to a substance or known physiological condition (F98.1) | 1 | |
| Other abnormal auditory perceptions (H93.2) | 1 | |
| Patients with comedication, n (%) | 22 | |
| One comedication | 19 | (86.4) |
| More than one comedication | 3 | (13.6) |
| Comedication, n (%), multiple entries | ||
| Clozapine | 1 | (4) |
| Lamotrigine | 1 | (4) |
| Lisdexamphetamine | 1 | (4) |
| Methylphenidate | 9 | (36) |
| Olanzapine | 1 | (4) |
| Pipamperone | 2 | (8) |
| Propiverine | 1 | (4) |
| Risperidone | 7 | (28) |
| Sodium valproate | 1 | (4) |
| Sulpiride | 1 | (4) |
| Therapeutic efficacy, n (%) | 60 | |
| Low efficacy | 5 | (8.3) |
| Moderate efficacy | 28 | (46.7) |
| Strong efficacy | 27 | (45) |
| Side effects, n (%) | 56 | |
| Severe side effects | 8 | (14.3) |
| Moderate side effects | 5 | (8.9) |
| Minor/no side effects | 43 | (76.8) |
SD standard deviation, min minimum, max maximum, ICD-10 International statistical classification of diseases and related health problems