. 2022 May 7;129(7):925–944. doi: 10.1007/s00702-022-02504-6

Table 4.

Percentage of monotherapy with antidepressant (ADD) or antipsychotic drugs (APD) defined as one drug without concomitant use of any other psychotropic drug and mean number of psychotropic drugs, ADD, and APD per patient according to severity of major depressive disorder (MDD)

		Moderate MDD	Severe MDD	Psychotic MDD	Overall: X²(2,43,868)	Moderate vs. severe: X²(1,38,278)	Moderate vs. psychotic: X²(1,17,906)	Severe vs. psychotic: X²(1,31,552)
ADD monotherapy	Any	23.2%	17.1%	4.4%	954.9, p < 0.001, V = 0.10	201.5, p < 0.001, ϕ = 0.07	948.5, p < 0.001, ϕ = 0.23	586.7, p < 0.001, ϕ = 0.14
	SSRI	9.3%	6.1%	1.5%	400.1, p < 0.001, V = 0.07	129.2, p < 0.001, ϕ = 0.06	36,594, p < 0.001, ϕ = 0.14	194.4, p < 0.001, ϕ = 0.08
	NaSSA	5.3%	4.3%	1.2%	163.2, p < 0.001, V = 0.04	18.9, p < 0.001, ϕ = 0.02	167.5, p < 0.001, ϕ = 0.10	122.4, p < 0.001, ϕ = 0.06
	SSNRI	5.0%	3.7%	0.8%	190.6, p < 0.001, V = 0.05	35.8, p < 0.001, ϕ = 0.03	190.9, p < 0.001, ϕ = 0.10	125.4, p < 0.001, ϕ = 0.06
	TCA	1.4%	1.7%	0.1%	84.6, p < 0.001, V = 0.03	4.8, p < 0.05, ϕ = 0.01	66.0, p < 0.001, ϕ = 0.06	84.3, p < 0.001, ϕ = 0.05
APD monotherapy		1.9%	1.8%	3.1%	40.6, p < 0.001, V = 0.02	0.5, p = 0.50, ϕ < 0.01	24.9, p < 0.001, ϕ = 0.04	39.1, p < 0.001, ϕ = 0.04
Number of psychotropic drugs per patient	> 2	35.5%	46.3%	66.6%
	2	31.0%	30.2%	24.3%
	1	26.9%	20.0%	7.8%
	0	6.6%	3.5%	1.3%
Mean number of psychotropic drugs		2.2 ± 1.3	2.5 ± 1.4	3.1 ± 1.3	949.3, p < 0.001, η² = 0.041	p < 0.001, η² = 0.013	p < 0.001, η² = 0.041	p < 0.001, η² = 0.019
Mean number of ADDs		1.1 ± 0.7	1.2 ± 0.6	1.1 ± 0.6	66.5, p < 0.001 V < 0.001, η² = 0.003	p < 0.001, η² = 0.001	p = 0.42, η² < 0.001	p < 0.001, η² = 0.001
Mean number of APDs		0.4 ± 0.6	0.6 ± 0.7	1.1 ± 0.7	2003.2, p < 0.001, η² = 0.084	p < 0.001, η² = 0.010	p < 0.001, η² = 0.084	p < 0.001, η² = 0.060