. 2022 May 23;96(8):2361–2380. doi: 10.1007/s00204-022-03309-y

Table 3.

CSAFs of R- and S-methadone for the Caucasian population, the Chinese population and the two populations combined, in each scenario of Monte Carlo simulation taking into account variations in metabolism, bodyweight, oral fraction absorbed and fraction unbound in plasma

	CSAFs at 95th percentile			CSAFs at 99th percentile
	Caucasian population^a	Chinese population^a	Two populations combined^b	Caucasian population^a	Chinese population^a	Two populations combined^b
R-methadone	2.4 (1.7)	1.9 (1.2)	4.5 (3.0)	3.1 (2.0)	2.5 (1.3)	5.8 (3.2)
S-methadone	2.5 (1.9)	2.1 (1.3)	6.7 (4.5)	3.3 (2.3)	2.6 (1.4)	8.3 (4.7)

Values between brackets are the CSAFs derived on the metabolic variation only

^aObtained by dividing the 95th or 99th percentile of the unbound C_max in heart venous blood by the GM of the unbound C_max in heart venous blood in each population

^bObtained by dividing the 95th or 99th percentile of the unbound C_max in heart venous blood in the Chinese population by the GM of the unbound C_max in heart venous blood in the Caucasian population