Table 4.
The predicted BMDL10 values for the average and the sensitive (99th percentile of predicted Cmax in heart venous blood) of the Caucasian and Chinese population obtained by the CSAFs derived from the Monte Carlo simulation considering variations in metabolism, bodyweight, oral fraction absorbed and fraction unbound in plasma
| Caucasian population | Chinese population | |||
|---|---|---|---|---|
| R-methadone | S-methadone | R-methadone | S-methadone | |
| BMDL10 (mg/day) for the average population | 99.6 | 18.7 | 39.5 | 5.1 |
| BMDL10 (mg/day) for sensitive population | 32.4 | 5.5 | 15.8 | 1.9 |