Table 4.

C. elegans SIN-3 protein interactors involved in apoptosis, autophagy and longevity.

S. no.	Name of protein	Function	References
1	HLH-3	Induction of programmed cell death, regulation of axon extension involved in axon guidance; regulation of oviposition	62,63
2	CES-2	Promotes programmed cell death and autophagy	63–65
3	DAF-16	Supports resistance to oxidative stress and longevity, apoptosis, defense response to other organism; regulation of dauer larval development; regulation of primary metabolic process	66–72
4	BAR-1	Life-span regulation, multicellular organism development; reproductive behavior; signal transduction	73,74
5	AKT-1	Induction of DNA damage-dependent apoptosis, inhibition of apoptosis, cellular protein modification process; determination of adult lifespan; signal transduction	75–78
6	AKT-2	Induction of DNA damage-dependent apoptosis, inhibition of apoptosis, cellular protein modification process; determination of adult lifespan; insulin receptor signaling pathway	75–77
7	SIR-2.1	Chromosome organization, determination of adult lifespan, induction of p53/cep-1 independent apoptosis, and autophagy	79–82
8	SGK-1	Determination of adult lifespan, mesendoderm development; peptidyl-serine phosphorylation; regulation of protein localization to basolateral plasma membrane	83–86
9	RLE-1	Determination of adult lifespan, response to heat; and ubiquitin-dependent protein catabolic process	87,88
10	FOS-1	Cell invasion, lifespan regulation	89,90
11	SET-1	Embryo development, histone methylation, apoptosis lifespan regulation	91–94
12	PHA-4	Multicellular organism development; determination of adult lifespan; positive regulation of cellular metabolic process; response to caloric restriction	68,95,96
13	HCF-1	Dauer exit; determination of adult lifespan	97
14	DAF-12	Determination of adult lifespan; heat acclimation; positive regulation of dauer larval development	98–101
15	JUN-1	Determination of adult lifespan; response to starvation	102