Table 2.
Signature genes and their relevance to PCa and/or other cancers.
| Symbol | Name | Relevance with cancer/tumor/patient and references |
|---|---|---|
| CDKN1A | cyclin dependent kinase inhibitor 1A | Variants; advanced PCa25 |
| DDB1 | damage specific DNA binding protein 1 | Apoptosis, chemo-resistance regulation and progression; multiple cancer types26–28 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | Cell growth, metastasis, chemotherapy resistance; multiple cancer types29,30 |
| GCDH | glutaryl-CoA dehydrogenase | |
| GK3P | glycerol kinase 3 pseudogene | |
| KIAA0196 | Strumpellin | Amplified and overexpressed; PCa31 |
| LARP4B | La ribonucleoprotein 4B | Cell migration and invasion; PCa32 |
| NAA50 (NAT13) | N-alpha-acetyltransferase 50, NatE catalytic subunit | |
| NDUFA9 | NADH: ubiquinone oxidoreductase subunit A9 | Cell Proliferation, Metastasis; breast cancer33 |
| NFATC3 | nuclear factor of activated T cells 3 | Tumor growth, cell proliferation and migration; astroglioma34 |
| NUMB | NUMB endocytic adaptor protein | Invasion, metastasis, migration; melanoma 35, colon cancer36 |
| OIP5 | Opa interacting protein 5 | Growth, metastasis and drug-resistance; bladder cancer37 |
| PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Glycolysis, cell proliferation; pancreatic cancer38 |
| PLEKHF2 | pleckstrin homology and FYVE domain containing 2 | Amplified, Survival; PCa39 |
| RASIP1 | Ras interacting protein 1 | Cell migration; non-small-cell lung cancer cells lines40 |
| RNF167 | ring finger protein 167 | Activates mTORC1 and promotes tumorigenesis; breast and liver cancer cell lines. 41 |
| SELENBP1 | selenium binding protein 1 | Tumor growth, progression, survival; lung cancer42, PCa43 |
| SLC45A3 | solute carrier family 45 member 3 | SLC45A3-ERG fusion, survival; PCa43 |
| SMC4 | structural maintenance of chromosomes 4 | TGFβ/Smad signaling, cell invasion; glioma cells44, PCa45 |
| TMEM87A | transmembrane protein 87A | Cell proliferation and metastasis; gastric cancer46 |
| UBXN2B | UBX domain protein 2B | |
| SRSF10 (SFRS13A) | serine and arginine rich splicing factor 10 | Maintenance of oncogenic features; colon cancer cells47 |
| C3orf67 | Chromosome 3 open reading frame 67 | |
| C14orf169 (NO66) | Chromosome 14 open reading frame 169 | Osteolytic lesions, invasion and metastasis; PCa48 |
| LOC678655 (CD27-AS1) | CD27 antisense RNA 1 | Progression; acute myeloid leukemia49 |