Table 2.

Comparison of clinical and genetic characteristics between sexes.

	Male (n = 249)	Female (n = 53)	Univariate p-value
Age	55.1 ± 11.3	61.6 ± 12.4	2.1 × 10–4
Bilateral involvement	72 (28.9%)	11 (20.8%)	0.23
Central retinal thickness (µm)	314 ± 130	384 ± 170	0.003
Subfoveal choroidal thickness (μm)	402 ± 115	331 ± 92	3.8 × 10–5
Baseline BCVA (log MAR)	0.21 ± 0.37	0.23 ± 0.35	0.62
Descending tract	45 (18.1%)	0 (0%)	8.0 × 10–4
Pachydrusen	65 (26.1%)	17 (32.1%)	0.37
Fibrin	16 (6.4%)	3 (5.7%)	0.83
Pigment epithelial detachment	33 (13.3%)	8 (15.1%)	0.72
CFH I62V (rs800292)
GG	57 (22.9%)	17 (32.1%)
GA	129 (51.8%)	22 (41.5%)
AA	63 (25.3%)	14 (26.4%)
A allele frequency	51.2%	47.2%	0.45
CFH rs1329428
CC	40 (16.1%)	13 (24.5%)
CT	138 (55.4%)	24 (45.3%)
TT	71 (28.5%)	16 (30.2%)
T allele frequency	56.2%	52.8%	0.52