Table 2.

Significant probe associations ($p<3.19e^{-7}$) detected across the 15 environmental exposure traits studied, as well as the 4 cluster PC1s.

Variable	Probe	Genes	Chr	Position	Method	β1	SE	p
Cadmium	cg03085637	GNRHR2;	1	145,918,458	Linear	1.86	0.29	9.4 × 10–11
		PEX11B			MOA	0.05	0.01	7.5 × 10–11
	cg21124714	P2RY6	11	73,272,052	Linear	− 1.54	0.3	2.6 × 10–7
					MOA	− 0.04	0.01	1.8 × 10–7
	cg16655883	ZFR2	19	3,868,626	Linear	1.18	0.23	2.7 × 10–7
					MOA	0.04	0.01	1.8 × 10–7
Chem PC1	cg093698632	LINGO1	15	77,820,505	Linear	11.68	2.25	2.1 × 10–7
					MOA	0.24	0.05	3.7 × 10–7
Mercury	cg03085637	GNRHR2;	1	145,918,458	Linear	1.72	0.33	1.3 × 10–7
		PEX11B			MOA	0.04	0.01	1.6 × 10–7
	cg16845679	N/A	12	114,624,854	Linear	− 0.85	0.16	2.0 × 10–7
					MOA	− 0.04	0.01	2.3 × 10–7
Metallurgy	cg07503918	PRKG1-AS1	10	52,308,834	Linear	1.39	0.25	1.8 × 10–8
					MOA	0.05	0.01	3.1 × 10–8
	cg100710912	KSR2	12	117,762,563	Linear	− 1.57	0.31	3.0 × 10–7
					MOA	− 0.05	0.01	4.4 × 10–7

¹MOA and linear not on the same scale.

²Probe is not methylome-wide significant for the MOA model, but is for the linear model.