Table 2.

Anesthetic mixtures: Exptl. data vs. ’full’- and ’null’-interaction models.

Midazolam [mg/kg]	Propofol [mg/kg]	Alfentanil [mg/kg]	exptl.${}^a$ Effect	Fit results, based on parameters from:
				Riccati${}^b$ 3-dim	Riccati${}^b$ 2-dim.	Hill${}^c$ No interaction
0.1	0	0	0.2	0.1		0.1
0.125	0	0	0.3	0.3		0.3
0.15	0	0	0.5	0.5		0.5
0.175	0	0	0.8	0.7		0.7
0.2	0	0	0.8	0.8		0.8
0	0.7	0	0.1	0		0.
0	1	0	0.3	0.3		0.3
0	1.3	0	0.9	0.9		0.9
0	1.6	0	1	1		1
0	1.9	0	1	1		1
0	2.2	0	1	1		1
0	2.5	0	1	1		1
0	0	0.05	0	0.1		0
0	0	0.075	0.3	0.2		0.2
0	0	0.1	0.5	0.6		0.6
0	0	0.125	0.9	0.8		0.8
0	0	0.15	1	1		0.9
0.03	0.21	0	0.2	0.2	0.2	0.0
0.04	0.29	0	0.4	0.4	0.4	0.0
0.05	0.36	0	0.5	0.6	0.6	0.0
0.065	0.46	0	0.8	0.8	0.3	0.3
0.085	0.6	0	1	0.9	0.8	0.7
0.1	0.71	0	1	1	0.9	0.9
0.13	0.92	0	1	1	1	1.0
0.17	1.2	0	1	1	1	1.0
0	0.25	0.025	0.1	0.1	0.0	0.0
0	0.31	0.031	0.3	0.2	0.2	0.0
0	0.4	0.04	0.4	0.5	0.6	0.1
0	0.5	0.049	0.8	0.7	0.8	0.5
0	0.63	0.061	0.9	0.9	0.9	0.9
0.035	0	0.025	0.4	0.4	0.0	0.0
0.044	0	0.031	0.7	0.7	0.2	0.1
0.056	0	0.04	0.9	0.9	0.6	0.3
0.07	0	0.049	0.9	0.9	0.8	0.5
0.085	0	0.061	1	1	0.9	0.8
0.023	0.17	0.016	0.3	0.3		0.
0.03	0.21	0.021	0.6	0.6		0.
0.037	0.26	0.026	0.8	0.8		0.1
0.047	0.33	0.032	0.9	0.9		0.5
0.059	0.42	0.041	1	1		0.8

${}^{\text{a}}$Data from⁴¹, 0 = no hypnosis, 1 = full hypnosis.

${}^{\text{b}}$Full-interaction model $u_{\mathit{Ricc}}$, Eqs. (8) and (23), interaction parameters from Table 1.

${}^c$ Hill’s equation for pure compounds, null-interaction model $u_{\mathit{Hill}}$ , Eq. (4), else.