Table 1.

METTL1 regulated tumor progression by confirmed association with m⁷G

Tumors	Role in tumors	m7G target	Mechanisms	Reference
Head and neck cancer	accelerator	tRNA	activated the PI3K/Akt/mTORC signaling pathway, RPTOR/ULK1/autophagy axis, and Wnt/β-catenin pathway, as well as promoted the cyclin D1 translation	44,45
Lung cancer	accelerator	tRNA	promoted translation of cell-cycle genes including cyclin D3 and cyclin E1	32
	suppressor	miRNA	promoted transcription of let-7e miRNA and inhibited expression of HMGA2	19
Liver cancer	accelerator	tRNA	promoted the translation of cell-cycle genes including cyclin A2, cyclin D2, CDK6, and CDK8 as well as activated EGFR, VEGFA, and MAPK signaling pathways	52,54
Colon cancer	suppressor	miRNA	promoted transcription of let-7e miRNA and inhibited expression of HMGA2	56
Bladder cancer	accelerator	tRNA	promoted the translation of EGFR and EFEP1 and activated EGFR pathway	59
Teratoma	suppressor	tRNA	promoted translation of pluripotency genes, including Oct4, Nanog, and Sox2, as well as activated cell-cycle signaling pathway	29